Clinical Aspects of RA Flashcards

1
Q

What are some of the general treatments for RA?

A

Medicines
Injections
Therapies
Surgery

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2
Q

What are the four different categories of therapeutics?

A

NSAIDs
Disease Modifying Anti-Rheumatic Drugs (DMARDs)
Biologics
Coricosteroids (oral, IM, IA)

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3
Q

what are the most commonly used DMARDs?

A

methotrexate
sulfasalazine
hydroxychloroquine
leflunomide

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4
Q

give some examples of biologics

A
TNFa inhibitors
IL-1 inhibitors (anakinra)
anti-B cell therapies (CD20, rituximab)
anti-T cell therapies (abatacept)
IL-6 inhibitors (tocilizumab)
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5
Q

what is the eular criteria for RA?

A

A. Joint involvement

  • 1 large joint - 0
  • 2-10 large joints - 1
  • 1-3 small joints (with/out large joints) - 2
  • 4-10 small joints (with/out large joints) - 3
  • > 10 joints (at least 1 small joint) - 5

B. Serology

  • negative RF and negative ACPA - 0
  • low-positive RF or low-positive ACPA - 2
  • high-positive RF or high-positive ACPA - 3

C. Acute phase reactants

  • normal CRP and normal ESR - 0
  • abnormal CRP or abnormal ESR - 1

D. Duration of symptoms

  • <6 weeks - 0
  • > 6 weeks - 1
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6
Q

what are the two components of RA’s aetiology

A

genetics and environment

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7
Q

what investigations should be done for ra

A

immunology - rheumatoid factor (IgG, IgM), anti cyclic citrullinated antibodies (anti CCP, ACPA)

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8
Q

symptoms of arthritis

A
pain
stiffness
immobility
poor function
systemic symptoms
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9
Q

clinical signs of arthritis

A
swelling
tenderness
limitation of movement
redness
heat
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10
Q

what are some of the non-specific systemic features of ra

A

fatigue
weight loss
anaemia

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