Clinical Aspect of Nephrotic Syndrome Flashcards
What histologic findings would be expected in a specimen from a patient with FSGS?
Focal and segmental sclerosis, subendothelial IgM deposits
IF microscopy of a kidney biopsy in a patient with membranous nephropathy will be positive for what?
IgG & C3 in the subepithelium
Solid organ malignancies are most associated with what nephrotic syndrome?
Membranous neuropathy
This nephrotic disorder is most common in African Americans.
Focal segmental glomerulosclerosis
Membranous neuropathy is most common among what population?
Middle-age caucasians
True/False. Minimal change disease is responsive to corticosteroids.
True - In children with suspected MCD, corticosteroids are given empirically, without a kidney biopsy
Henoch0Schonlein purpura is most associated with what kidney disorder?
IgA Nephropathy
Tram-tracking is characteristic of what nephrotic disorder?
Membranoproliferative Glomerulonephritis (MPGN)
What is the number one form of idiopathic glomerulonephritis worldwide?
IgA Nephropathy
This type of MPGN is due to antibodies against C3 nephritic factor, causing hyperactivation of the alternative complement pathway.
Type II MPGN
HCV is most associated with what nephrotic disorder?
Membranoproliferative Glomerulonephritis (MPGN)
What is the leading cause of end-stage renal disease among nephrotic disorders?
Membranous neuropathy
How do Type I & Type II MPGN differ?
Type I - IgG & C3 subendothelial deposits
Type II - C3 intramembranous deposits
HIV is most associated with what nephrotic disorder?
Focal segmental glomerulosclerosis (FSGS)
What is the most common nephrotic disorder seen in children?
Minimal change disease
