Class 15 - Dysexecutive syndromes Flashcards

1
Q

Who is Phineas Gage

A

He had a railroad spike through his frontal lobe. And then he became an asshole

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2
Q

Where do you damage when you lose fine movements, speed and strength?

A

Primary motor cortex

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3
Q

Where do you damage when you lose movement programming?

A

Premotor or dorsolateral cortex

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4
Q

Where do you damage when you have changes in voluntary gaze?

A

Frontal eye fields

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5
Q

What is corollary discharge or reafference? Is it frontal lobe mediated?

A

When a movement is about to occur, there is an internal neural signal that movement will occur. Yes

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6
Q

Where do you damage when you have mutism?

A

Supplementary motor cortex

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7
Q

Where do you damage when you have agrammatism?

A

Broca’s area

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8
Q

What is convergent thinking?

A

When there is only one answer to the question

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9
Q

What is divergent thinking?

A

Questions that ask for a variety of responses

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10
Q

What indicates a loss of behavioral spontaneity

A

Decreased verbal fluency, decreased design fluency, reduction in general behaviors

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11
Q

A deficit in what type of function can result in: increased perserveration (cannot shift), inability to plan, loss of response inhibition?

A

Executive function deficit

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12
Q

what types of memory are poor in executive function deficit patients?

A

Temporal and working memory

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13
Q

What is pseudodepression?

A

Apathy, loss of initiative, reduced sexual interest, little or no verbal output

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14
Q

What is pseudopsychopathy?

A

Immature behavior, lack of restraint, promiscuous sexual behavior, lack of social graces

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15
Q

What circuit is damaged in dysexecutive syndrome?

A

Dorsolateral circuit

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16
Q

What circuit is damaged in pseudodepression (apathy)?

A

Ventromedial anterior cingulate circuit

17
Q

What circuit is damaged in pseudopsychopathy (impulsivity)?

A

Orbitofrontal circuit

18
Q

What frontal lobe changes cause schizophrenia?

A

Decrease blood flow to the frontal lobes, frontal lobe atrophy. Also abnormal mesocortical dopaminergic projections

19
Q

What frontal lobe changes cause Parkinson’s disease?

A

Loss of dopamine cells in the substantia nigra that project to the prefrontal cortex

20
Q

What frontal lobe changes result in Korsakoff’s syndrome?

A

A deficiency of frontal lobe catecholamines and damage to the dorsomedial thalamus

21
Q

What are the three variants of frontotemporal dementia?

A

Behavioral, primary progressive aphasia, movement disorders (corticobasal degeneration, progressive supranuclear palsy)

22
Q

What are three changes in Lewy body dementia?

A

Changes in movement (Parkinsonian), behavior (fluctuating alertness, psychosis), cognitive ability