Circadian rhythms Flashcards

1
Q

How long is circadian cycle?

A

20-28 h

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2
Q

How long is ultradian cycle?

A

Less than 20 hours

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3
Q

How long is circamensual cycle?

A

30 days

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4
Q

How long is infradian cycle?

A

Less than 38 hours

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5
Q

How long is human period?

A

25 hours

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6
Q

Where is SCN?

A

Anterior hypothalamus

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7
Q

RHT

A
  • Signal from light-dark cycle through retinal hypothalamic tract which is glutamatergic
  • Glutamate into SEN - activates neurons
  • SEN ontop of optic chiasm
  • Circadian rhythms are endogenous - not driven by light-dark cycle
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8
Q

When does real time start?

A

0

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9
Q

What is ZT 0?

A

Lights on

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10
Q

What is ZT 12?

A

Lights off

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11
Q

What is CT 0?

A

Subjective lights on

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12
Q

What is CT 12?

A

Subjective lights off

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13
Q

What is the phase of a clock?

A

How delayed a cycle is compared to lights on

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14
Q

What is phase advance?

A

How delayed a cycle is compared to lights on

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15
Q

How do clocks work?

A

BMAL1 and CLOCK activate PER-CRY

PER-CRY inhibit BMAL1 and CLOCK

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16
Q

When is SCN more hyper polarised and depolarised?

A

Night and day

17
Q

Do SCN cells contain GABA?

A

Yes

18
Q

Why are glial cells good?

A

Support electrical conductivity

19
Q

How does the retina communicate with the SCN?

A

RHT and glutamate PACAP

20
Q

How does the intergenticulate leaflet communicate with the SCN?

A

Geniculohypothalamic tract

21
Q

How does Median Raphe communicate with the SCN?

A

Serotonin

22
Q

Processes regulated by SCN

A
  • Vasoactive intestinal polypeptide
  • Vasopressin
  • Prokineticin
  • Neuromedin
  • Enkephalin
  • Help circadian rhythm in other areas of body
  • Physiology and behaviours: memory/reward/sleep/temperature/metabolism etc
  • Helps with cell cycle progression, DNA repair, cell detoxification
  • Master clock organises clocks in all tissues
23
Q

Where is melatonin released?

A

Pineal gland

24
Q

How do the PVN and SCN communicate?

A

HPA axis

25
Q

What is chronotype?

A

Variation of circadian cycle within population

26
Q

What is released in stressful situations?

A

Cortisol

27
Q

What causes chronodisruption?

A

Internal/external factors, interrupted schedule

28
Q

Treatment for interrupted SCN

A

Bright light therapy - increases sleep, higher daytime activity and lower daytime sleep
Melatonin - increases sleep, decreases nocturnal activity