Chronic Inflammation and Autoimmunity

Question 1

What is a pathological condition involving persistent, increased expression of inflammatory cytokines?

Answer 1

Chronic inflammation

Question 2

What is the most common cause of non-infectious chronic inflammation today?

Answer 2

Obesity

Question 3

True or false. Chronic inflammation is caused by non-infectious factors?

Answer 3

False. Chronic inflammation is caused by infectious and non-infectious factors

Question 4

Scar tissue
Insulin resistance (type II diabetes)
Increased levels of pro-inflammatory cytokines
Organ dysfunction
…are all consequences of what?

Answer 4

Chronic inflammation

Question 5

The occurence of some ‘self’ directed reactivity, nit necessarily associated with disease describes what?

Answer 5

Autoimmunity

Question 6

Hashimoto thyroiditis, Systemic lupus erythematosus, Rheumatoid arthritis, Myasthenia gravis
…are all example of what?

Answer 6

Autoimmune diseases

Question 7

Where does central tolerence occur?

Answer 7

Primary lymphoid organs

Question 8

Express CTL-4, Express TCR with high affinity for self-antigen, CD25 positive, Foxp3…are all structural features of what?

Answer 8

Regulatory T cell

Question 9

Functions of regulatory T cell (Treg)

Answer 9

Regulating and inhibiting other cells in the immune system
Signalling through CD80/CD86
Activation of indoleamine 2.3-dioxygenase (IDO)
Making inhibitory cytokines

Question 10

What autoimmunity disease involves the production of auto-antibodies and sensitised Th1 cells specific for thyroglobin and thyroid peroxidase?

Answer 10

Hashimoto thyroiditis

Question 11

What type of of autoimmune disease is Hashimoto thyroiditis?

Answer 11

Organ specific

Question 12

What type of autoimmune disease is Myasthenia gravis?

Answer 12

Tissue specific

Question 13

What type of autoimmune disease is Systemic Lupus erythematous

Answer 13

Systemic

Question 14

What type of autoimmune disorder is rheumatoid arthritis?

Answer 14

Systemic