Antibody-Mediated/Humoral Immunity Flashcards
What are Streptococcus pneumonia, vibrio cholera, and Neisseria gonorrhoea examples of?
Extracellular bacterial pathogens
What are worms an example of?
Extracellular parasitic pathogen
What can antibodies only attach to?
Their specific antigen
What are antibodies produced by?
B lymphocytes
What immunoglobin has a monomeric and dimeric form?
IgA
What immunoglobin is secreted later in the primary response and is the main antibody calss in the secondary response?
IgG
What is the first antibody class secreted in the primary response?
IgM
What antibody exists as a dimer in secretions via J-chain?
IgA
Which immunoglobin is primarily involved in allergic reactions?
IgE
Which immunoglobin is the most common circulating antibody isotope and can be transferred through the placenta?
IgG
Which antibody is the most important in protecting against gut infections?
IgA
Which antibody is most abundant in body fluids?
IgG
Which antibody is predominantly present in breast milk and colostrum?
IgA
What is the first antibody expressed on a B cell?
IgM
Which antibody binds to FcεR1 on mast cells?
IgE
Which antibody binds to FcγR on macrophages?
IgG
Which antibody is mainly secreted from mucosal surfaces?
IgA
Which antibody is a pentamer?
IgM
Why are T-independent responses fast?
Because B cells are directly activated by antigens with certain types of structure
What is the only antibody class that can be produced in T-independent response?
IgM
Humoral immunity is mediated by…?
B cells
Humoral immunity is also known as?
Antibody-mediated immunity
what happens to B cells upon activation by antigens?
Undergo clonal selection followed by clonal expansion
