Cell Mediated Immunity Flashcards
What is the difference between humoral and cell-mediated immunity?
Humoral immunity is triggered by B cells and cellular immunity is triggered by T cells
What type of immunity protects the body by:
activating macrophages and NK cells
Stimulates cytokine secretion
Activates antigen-specific cytotoxic T cells (CD8+)
Cell-mediated immunity
What are Mycobacterium Tuberculosis and Listeria monocytogenes examples of?
Intracellular bacterial pathogens
What is Herpes simplex virus an example of?
Intracellular viral pathogen
What are Trypanosoma brucei, Toxoplasma gondii, and Leishmania spp. examples of?
Intracellular parasitic pathogens
What type of T cell helps other T cells by stimulating immunity and recognises MHC-II through the CD4 receptor?
T-helper cells
What type of T cell is able to kill infected cells directly and recognises MHC-1 through CD8 receptor?
Cytotoxic T cells (T-killer)
What type of T cell suppresses the actions of activated T cells once the threat has ended, preventing over activity?
T-suppressor cells
What type of T cell creates larger and faster responses upon repeated exposure and is converted into large numbers of T-helper and cytotoxic cells?
T-memory cells
What class of MHC aids in differentiation between self and foreign cells or pathogens?
MHC-I (CD8)
Which class of MHC is present on APCs alongside MHC-I and presents phagocytosed pathogens?
MHC-II (CD4)
Certain Ags activate specific populations of Th cells secreting cytokines that induce what?
Type IV Hypersensitivity (DTH)
What is a Type IV Hypersensitivity (DTH)?
Massive inflammatory cell infiltration, in particular macrophages, to kill phagocytosed microbes/pathogens
