Chapter 73: Osteochondrosis Flashcards

1
Q

What percentage of all dogs presented for orthopedic problems are diagnosed with OCD?

What % of dogs presenting for ortho problems at under 1 year of age are diagnosed with OCD?

A

3.7% of ALL orthopedic dogs

9% of orthopedic dogs under 1 year.

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2
Q

Male dogs are more commonly affected with OCD at all locations except where?

A

Females are more common for OCD of the talus (tarsus).

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3
Q

In most long bones, growth plates (physes) contribute ____% of final bone length whereas epiphyses contribute approximately ____%?

A

Growth plates contribute MOST 75-80% of final bone length (IMPORTANT)

Epiphyses contribute approx. 20-25%

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4
Q

At what age does the medial aspect of humeral condyle (a center of ossification) fuse to the lateral condyle?

A

6 weeks

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5
Q

What is saltation and stasis?

Which bones of the dog are known to experience it?

A

In human children, short periods of active growth alternate with longer periods with no measurable growth.
Saltation is growth and stasis is obvious.

Saltatory growth has been demonstrated in the dog radius, ulna and tibia.

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6
Q

What is the Hueter-Volkmann law and what does it describe?

A

Growth is retarded by increased mechanical compression and accelerated by reduced loading.

This fits with studies in lambs where 90% of growth-plate related bone lengthening occurred while they were lying down and nearly none when standing.

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7
Q

What are the (4) zones of the physis?

A

Resting (epiphyseal side)
Proliferative
Hypertrophic
Mineralization

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8
Q

In the outer layer of the articular-epiphyseal complex, what does the presence of the tidemark indicate?

A

The tidemark is a microscopically visible line that represents the separation of the zone of calcified cartilage from the radial zone.

Emergence of the tidemark indicates that cartilage maturation is complete.

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9
Q

Olsson and Reiland described two types of OCD. Most of our understanding is based on study of Type 1 lesions.

What are the two types, and where are they found?

A

Type 1: Occurs at the center of the affected articular surface, away from vascular attachments.
- Sites include the caudal humeral head, medial humeral condyle, lateral and/or medial femoral condyles (IMPORTANT)

Type 2: Occurs at joint margin and retains vascular attachment.
- Sites include medial or lateral trochlear ridges of talus (which attach to joint capsule and/or ligaments) and MCP of ulna (which is vascularized through joint capsule or the annular ligament)

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10
Q

There is a grading scheme for OCD of the proximal humerus that grades from I to IV. What does a lesion of each type look like?

A

Type I: Cartilage surface normal, cartilage slightly thickened, miniscule subchondral bone defect
Type II: Cartilage surface mottled, more thickened, small “cleft” of subchondral bone
Type III: Discoid elevation of cartilage surface. Underlying bone sclerotic
Type IV: Typically a partially or fully detached flap and joint mice

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11
Q

What are the three stages of OCD?

A

Oseochondrosis Latens
Osteochondrosis Manifesta
Osteochondrosis/itis dissecans

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12
Q

Describe the lesion of osteochondrosis latens?

A

Early, microscopic

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13
Q

Describe the lesion of Osteochondrosis manifesta?

A

Subclinical lesion that is both macroscopically and radiologically apparent.

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14
Q

Describe the lesion of Osteochondrosis dissecans?

Why is this also called Osteochondritis, even though it isn’t inflammatory in pathology?

A

An attached or loose cartilage flap is present. These dogs are usually clinically affected.

Because the flap causes synovitis, this is often referred to conventionally as an -itis even if the pathology is not truly inflammatory.

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15
Q

What is the incidence of OCD in cats?

A

0.001%

There are only a few cases in the literature, considered very uncommon.

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16
Q

What prevents circumferential expansion of the growth plate?

A

The perichondral ring of Lacroix.

17
Q

The articular-epiphyseal complex, at the cartilaginous end of developing bone, has two layers.
The inner layer is like a physis. The outer layer is immature cartilage and is avascular. It has four zones - what are they?

A

Superficial zone
Transitional zone
Radial zone
(Tidemark)
Zone of calcified cartilage

18
Q

OCD is considered a polygenetic trait, but there is a strong breed and bloodline predisposition. What is the reported range of heritability of OCD (in %)?

A

10-45%

19
Q

Most long bone growth in dogs occurs between what ages?

A

12-26 weeks of age (IMPORTANT)

20
Q

What are four risk factors for OCD?

A

Heredity
Rapid growth
Diet
Trauma
(IMPORTANT)

21
Q

What is thought to be the cause of clinical signs with a OCD lesion?

A
  • Joint fluid coming into contact with subchondral bone may elute necrotic cartilage particles or inflammatory mediators and provoke a synovitis
  • Inflammatory mediators within synovial fluid can stimulate nociceptors in subchondral bone
  • Altered loading
22
Q

How has microtrauma been speculated to cause OCD?

A

Microtrauma can cause damage to cartilage canal vessels at the chondroosseous junction and subsequent necrosis of cartilage canals leading to areas of cartilage ischemia and necrosis.

23
Q

What remains once the process of epiphyseal ossification is finished?

A

A thin layer of avascular articular cartilage and a cartilage disc between the epiphysis and metaphysis (growth plate)

24
Q

What substances are involved in the local feed-back loop of chondrocyte proliferation?

A
  • PTHrP
  • IHH (Indian hedgehog)
  • TGF-B

Controls the irreversible differentiation of proliferative chondrocytes into hypertrophic chondrocytes. BMP, thyroid hormone and others are also needed for this phenotypic change to occur. (IMPORTANT)

25
Q

What effect does growth hormone have on the resting zone of cartilage?

A
  • Promotes differentiation into daughter cells capable of making Insulin-like growth factor 1 (IGF-1) which stimulates clonal expansion of chondrocytes. (IMPORTANT)
26
Q

Describe the chondrocyte appearance in each of the physeal zones:

A
  • Resting zone: Small, scattered, randomly organized. Primarily slowly dividing stem cells
  • Proliferative zone: Flat, relatively small, organized into COLUMNS. They divide, slowly enlarge and produce matrix
  • Hypertrophic zone: Spheroid and relatively large. Rapidly swell and continue synthesis of matrix
  • Mineralization zone: Newly formed matrix mineralizes and chondrocytes undergo apoptosis
27
Q

Which is the only vascularized zone of the physis?

A

The resting zone
- Penetrated by chondro-epiphyseal blood vessels within cartilage canals

28
Q

What are the widely accepted locations of OCD?

A
  • Humeral head
  • Medial aspect of humeral condyle
  • Lateral or medial femoral condyle
  • Medial or lateral trochlear ridge of the talus
29
Q

What are the main processes of endochondral ossification?

A
  • Matrix mineralization
  • Chondrocyte death
  • Vascularization
  • Ossification