Chapter 6 (pdf 14) Flashcards
6-carbon sugar converted to 3-carbon pyruvate
glycolysis
during this process substrate level phosphorylation created ATP
glycolysis
oxidation of intermediates produced reduced electron carriers
glycolysis
oxidation of CoA to CO2
TCA cycle
production of intermediates critical to biosynthesis and respiration
TCA cycle
Harvest reduced NADH
respiration
uses electrons from these substrates to convert potential energy to proton motive force then subsequently ATP
respiration
when used gets ‘highest’ return of energy
respiration
partial oxidation of glucose
fermentation
ATP production by ‘glycolysis’
fermentation
uses pyruvate ( or derivative) as terminal electron acceptor
fermentation
major function to provide building blocks including 5-carbon sugars RNA and DNA
pentose phosphate pathway
anabolic electron carrier NADPH
pentose phosphate pathway
Streptococcus
obligate fermenter
Nocardia
obligate aerobe
Saccharomyces
facultative anaerobe
pathways modify organic molecules to form
- High energy intermediates* to form ATP
- Intermediates* to generate reducing power
- Intermediates* and end products as precursor metabolites
pathways
- Glycolysis
- Pentose phosphate pathway
- TCA cycle
- -> make all DNA, proteins, and lipids for survival
two stages of pentose phosphate pathway
oxidative and non oxidative reactions
Generates 5 and 6 carbon sugars
- also produces glyceraldehyde 3-phosphate
- —-can go into glycolysis for farther breakdown
pentose phosphate pathway
pathway is a major contributor to biosynthesis
- produces reducing power NADPH
- two vital precursor metabolites
pentose phosphate pathway
Embden–Meyerhof pathway
Glycolysis
primary pathway to convert one glucose to two pyruvate
-10 step process
Glycolysis
pathway generates 3-C pyruvate molecules
Glycolysis
pathway generates a net gain of two ATP
- 2 ATP expended to break glucose
- 4 ATP harvested
Glycolysis
generates two molecules reducing power
-NADH
Glycolysis
“Group Transport” no concentration gradient is
formed
Glycolysis
•Transport is “generally” regulated by transcription in
response to availability
Glycolysis
Sweet fruit sugar F-6-P
Glycolysis
Energy consuming
Glycolysis
•Non-symmetrically cleavage
Glycolysis
Production of 2x reduced NADH
Glycolysis
Substrate level phosphorylation of ADP to
form ATP
Glycolysis
Production of reduced NADH
Glycolysis
Substrate level phosphorylation to ADP to form ATP
Glycolysis
‘Split’ of 6 carbon to two 3 carbon yields 4 ATP for the two consumed*
Glycolysis
What should you do with your pyruvate???*
- Fermentation
2. TCA for additional metabolites…and more NADH and FADH2