Chapter 5

Question 1

highly purified hb has

Answer 1

an extremely high affinity for O2 therefore limiting the ability of the protein to release oxygen to the periphery

Question 2

when studying the molecule 2,3 bisphosphate-d-glycerate, replacing components of blood showed what and therefore

Answer 2

the molecule 2,3 BPG decreased hemoglobin’s affinity for oxygen and therefore the molecule is a heterotropic allosteric inhibitor of hemoglobin

Question 3

fetal Hb comparted to adult Hb

Answer 3

fetal has a lower 2,3 BPG affinity therefore a higher oxygen affinity

Question 4

lower affinity for the allosteric inhibitor (2,3 BPG) means

Answer 4

a higher affinity for O2

Question 5

at higher altitudes, the increased 2,3 BPG

Answer 5

decrease the O2 affinity of Hb to maintain O2 delivery to the body

Question 6

the Bohr Effect describes and is used to

Answer 6

the pH dependence of hb’s affinity of O2

and is used to coordinate active tissues

Question 7

at decreased pH, hb

Answer 7

has a lower affinity for O2

Question 8

active tissues have lower pH than resting tissues through two mechanisms

Answer 8

• during exercise, increased muscle activity increases CO2 production which decreases pH
• in extreme exercise, muscle may produce lactic acid to drop pH even more

Question 9

CO2 is taken up into the red blood cells where hemoglobin is located and

Answer 9

coverted to bicarbonate and a proton by the enxyme carbonic anydrase

Question 10

the more active the tissues the

Answer 10

greater the production of CO2 and then the greater release of O2