Chapter 5 Flashcards
homotropic
when the normal ligand and modulator are the same
heterotropic
when the modulator is different from the normal ligand
allosteric proteins have what(R-state) and what(T-state)
active and inactive
what stabalizes the R state and what stabilizes the T state
allosteric activators and allosteric inhibitors
the binding and release of O2 from Hem
are allosterically regulated
binding the first O2 to hem causes
conformational changes making easier to bind more O2
O2 binding promotes and stabalizes
the R state which has higher O2 affinity than the T state
With T state hemoglobin the iron atom
is just outside the plane of the heme ring
with the pressures of oxygen found in the lungs:
Hb will completely saturate with O2
with the pressures of O2 found in the extremes of the body:
Hb will release approximately half of its O2
P50 of hb matches
the pressures of O2 found in periphery