Chapter 5

Question 1

ligand

Answer 1

molecule which is reversibly bound by protein

Question 2

myoglobin

Answer 2

monomeric protein that facilitates oxygen storage in peripheral tissue

Question 3

hemoglobin

Answer 3

protein that transports oxygen from lungs to periphery

Question 4

Heme consists of

Answer 4

protoporphyrin ring system bound to a single Fe atom

Question 5

Fe2+ needs six interactions:

Answer 5

four come from interactions with heme, fifth interaction witha histidine imidazole group, sixth is for O2 binding

Question 6

oxygen saturation curve is

Answer 6

hyperbolic

Question 7

the P50 of myglobin is

Answer 7

0.26 kPa

Question 8

the fraction of myoglobin saturated with oxygen can be calculated by

Answer 8

x= (pO2)/ (pO2) + (P50)

Question 9

hemoglobin is a what whose affinity for oxygen can be what

Answer 9

an allosteric protein -can be regulated through physiological signals

Question 10

allosteric effectors

Answer 10

bind to allosteric proteins at sites separate from the functional binding site