Chapter 5

Question 1

CO2 produced in the tissues can form what to then form what

Answer 1

form a covalent carbonate linkage to the N terminus of each chain to form carbaminohermoglobin

Question 2

The CO2 production and carbaminohemoglobin production has 3 important outcomes

Answer 2

• converts CO2 into a more soluble form
• carbamino has a lower O2 affinity to promote O2 release
• the proton released by the reaction will contribute to the O2 release through the Bohr Effect

Question 3

sickel cell anemia results from

Answer 3

a single amino acid change

Question 4

4 reasons why individuals with SCA have resistance to malaria

Answer 4

-malaria infects red blood cells and decreases the pH which will release O2 from Hb, deoxy HbS will form fibres deforming the shape of the red blood cells (with malaria in them) which are then destroyed by the spleen

Question 5

name three factors that stabilize the doxy form of hemoglobin

Answer 5

BPG binding, salt bridges between acidic and basic amino acids, salt bridges that include amino-terminal carbamate

Question 6

the prosthetic group of hemoglobin and myoglobin is

Answer 6

heme

Question 7

the central atom of heme is

Answer 7

Fe2+

Question 8

shape of hemoglobin and myoglobin

Answer 8

sigmoidal shape and hyperbolic shape

Question 9

which are bound to hemoglobin when it is in the R state

Answer 9

Fe2+, O2,