Chapter 319 - Cancer Immunotherapy

Question 1

What are the two primary immune cells responsible for direct tumour killing?
a) CD4 T cells and macrophages
b) Dendritic cells and neutrophils
c) CD8 T cells and NK cells
d) Regulatory T cells and monocytes

Answer 1

c) CD8 T cells and NK cells

Question 2

Which of the following is a strategy that tumours use to avoid immune elimination?
a) Increasing MHC molecule expression
b) Increased production of T cell metabolites
c) Secreting immune suppressive molecules (IL-10 and TGF-beta)
d) Expanding CD8 T cell populations

Answer 2

c) Secreting immune suppressive molecules (IL-10 and TGF-beta)

Question 3

Which drug has been shown to elicit effective tumour immunity by activating lung macrophages in dogs with metastatic osteosarcoma?
a) Losartan
b) Liposomal muramyl tripeptide (MTP)
c) Propranolol
d) Toceranib

Answer 3

b) Liposomal muramyl tripeptide (MTP)

Question 4

Which of the following is a characteristic of Chimeric antigen receptor (CAR) T cell therapy?
a) It is most effective for solid tumours
b) It requires multiple administrations
c) It works best with low T cell numbers
d) Most effective in hematopoietic cancers

Answer 4

d) Most effective in hematopoietic cancers

Question 5

What role do Regulatory T cells (Tregs) play in cancer immunity?
a) Directly killing tumour cells
b) Initiating and sustaining tumour immunity
c) Downmodulating tumour immunity
d) Producing tumour antigens

Answer 5

c) Downmodulating tumour immunity