Chapter 303 - Renal tubular diseases

Question 1

The proximal tubule re-absorbs what proportion of ultrafiltrate?
a. 10-15%
b. 25-30%
c. 45-50%
d. 60-65%

Answer 1

d. 60-65%

Question 2

Urine sediment analysis demonstrates the following. What breed has increased risk of formation of this?
a. Black Russian terrier
b. Basenji dog
c. Newfoundland dog
d. Cavalier King Charles spaniel

Answer 2

c. Newfoundland dog - cystine

Question 3

Genetic mutation of Slc2a9 is associated with which tubular disease?
a. Cystinuria
b. Hyperuricosuria
c. Primary renal glucosuria
d. Congenital nephrogenic diabetes insipidus

Answer 3

b. Hyperuricosuria

Question 4

Urine sediment analysis demonstrates the following. Which other disease is commonly associated with these crystals?
a. Dilated cardiomyopathy
b. Hypoadrenocorticism
c. Primary portal vein hypoplasia without portal hypertension
d. Primary hypoparathyroidism

Answer 4

c. Primary portal vein hypoplasia without portal hypertension

Urate (see other urate images)

Question 5

What pathophysiologic features exist in Dalmatians regarding uric acid metabolism and excretion?
a. Dalmatians have less uricase as non-Dalmatians, limiting uric acid metabolism
b. Dalmatians have abnormal uric acid transport across hepatic membranes, limiting uric acid metabolism
c. Dalmatians have less distal tubular secretion of urates compared to non-Dalmatians
d. Higher serum uric acid levels in Dalmatians predisposes to gout

Answer 5

b. Dalmatians have abnormal uric acid transport across hepatic membranes, limiting uric acid metabolism

Question 6

6) Consumption of chicken jerky treats can be associated with which renal syndrome?
a. Acquired nephrogenic DI
b. Acquired Fanconi syndrome
c. Carnitinuria
d. Cystinuria

Answer 6

b. Acquired Fanconi syndrome

Question 7

7) What treatment may be recommended for congenital nephrogenic diabetes insipidus?
a. Tiopronin and protein-restricted alkalising diet
b. Allopurinol and purine-restricted alkalising diet
c. The Gonto protocol
d. Free-choice water, protein restriction, thiazide diuretics

Answer 7

d. Free-choice water, protein restriction, thiazide diuretics

Question 8

8) Which low molecular weight protein urine biomarker may be a good predictor of GFR in dogs?
a. Beta 2 microglobulin
b. Neutrophil gelatinase-associated lipocalin (NGAL)
c. N-acetyl-B-D-glucosaminidase (NAG)
d. Immunoglobulin A

Answer 8

a. Beta 2 microglobulin