Chapter 303 - Renal tubular diseases Flashcards

1
Q

The proximal tubule re-absorbs what proportion of ultrafiltrate?
a. 10-15%
b. 25-30%
c. 45-50%
d. 60-65%

A

d. 60-65%

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2
Q

Urine sediment analysis demonstrates the following. What breed has increased risk of formation of this?
a. Black Russian terrier
b. Basenji dog
c. Newfoundland dog
d. Cavalier King Charles spaniel

A

c. Newfoundland dog - cystine

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3
Q

Genetic mutation of Slc2a9 is associated with which tubular disease?
a. Cystinuria
b. Hyperuricosuria
c. Primary renal glucosuria
d. Congenital nephrogenic diabetes insipidus

A

b. Hyperuricosuria

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4
Q

Urine sediment analysis demonstrates the following. Which other disease is commonly associated with these crystals?
a. Dilated cardiomyopathy
b. Hypoadrenocorticism
c. Primary portal vein hypoplasia without portal hypertension
d. Primary hypoparathyroidism

A

c. Primary portal vein hypoplasia without portal hypertension

Urate (see other urate images)

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5
Q

What pathophysiologic features exist in Dalmatians regarding uric acid metabolism and excretion?
a. Dalmatians have less uricase as non-Dalmatians, limiting uric acid metabolism
b. Dalmatians have abnormal uric acid transport across hepatic membranes, limiting uric acid metabolism
c. Dalmatians have less distal tubular secretion of urates compared to non-Dalmatians
d. Higher serum uric acid levels in Dalmatians predisposes to gout

A

b. Dalmatians have abnormal uric acid transport across hepatic membranes, limiting uric acid metabolism

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6
Q

6) Consumption of chicken jerky treats can be associated with which renal syndrome?
a. Acquired nephrogenic DI
b. Acquired Fanconi syndrome
c. Carnitinuria
d. Cystinuria

A

b. Acquired Fanconi syndrome

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7
Q

7) What treatment may be recommended for congenital nephrogenic diabetes insipidus?
a. Tiopronin and protein-restricted alkalising diet
b. Allopurinol and purine-restricted alkalising diet
c. The Gonto protocol
d. Free-choice water, protein restriction, thiazide diuretics

A

d. Free-choice water, protein restriction, thiazide diuretics

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8
Q

8) Which low molecular weight protein urine biomarker may be a good predictor of GFR in dogs?
a. Beta 2 microglobulin
b. Neutrophil gelatinase-associated lipocalin (NGAL)
c. N-acetyl-B-D-glucosaminidase (NAG)
d. Immunoglobulin A

A

a. Beta 2 microglobulin

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