Chapter 210 - Sinonasal and sino-orbital aspergillosis

Question 1

Il-10 has been associated with the pathophysiology of sinonasal aspergillosis in dogs. What is the function of Il-10?
a. Stimulation of the production of IFN-gamma
b. B cell differentiation
c. Anti-inflammatory/immune modulation
d. IgE production

Answer 1

c. Anti-inflammatory/immune modulation

Question 2

What is the specificity of a blind nasal swab culture in the diagnosis of nasal aspergillosis?
a. 100%
b. 75%
c. 50%
d. 25%

Answer 2

a. 100%

specificity is good regardless of method, sensitivity is best when culturing plaques

Question 3

Which of the following has been associated with improved treatment response when managing sinonasal aspergillosis?
a. Complete debridement
b. Concurrent use of systemic posaconazole
c. Soaking the nasal cavity with enilconazole solution for 1 hour
d. Depositing clotrimazole cream into the sinus via a non-invasive method (via rhinoscopy)

Answer 3

a. Complete debridement

15 minutes soak has been shown to be as good as 1 hour

Question 4

Which of the following antifungal should not be used systemically when managing aspergillus?
a. Terbinafine
b. Itraconazole
c. Amphotericin B
d. Fluconazole

Answer 4

d. Fluconazole

A. fumigatus is resistant to fluconazole

Question 5

Chronic nasal discharge occurs in what percentage of dogs following successful treatment of sinonasal aspergillosis?
a. 10%
b. 25%
c. 50%
d. 100%

Answer 5

c. 50%

Question 6

You diagnose a 7yo MN Persian with sino-orbital aspergillosis, what treatment would you recommend?
a. Enucleation
b. Enilconazole soak
c. Itraconazole
d. Posaconazole and terbinafine

Answer 6

d. Posaconazole and terbinafine

has also been used in refractory sinonasal aspergillosis in dogs

Question 7

Which of the following has been considered a risk factor for aspergillosis in cats?
a. FIV
b. Diabetes mellitus
c. Exposure to steroids
d. Exposure to imidocarb

Answer 7

b. Diabetes mellitus