Chapter 207 - Cryptococcosis Flashcards
Ocular involvement is seen in 1/3 cats with cryptococcosis and is strongly associated with CNS involvement, what ophthalmologic findings characterise this
a. Chorioretinitis and optic neuritis
b. Chemosis and keratitis
c. Anterior uveitis and secondary glaucoma
d. Pyogranulomatous anterior uveitis and Retinal vasculitis
A
(B = FHV, C = FIV, D= FIP)
What proportion of cats with cryptococcosis with nasal involvement have nasal swelling or ulcerative proliferative cutaneous lesions over the bridge of the nose?
a. 25%
b. 50%
c. 75%
d. 100%
B
Neurological signs due to extension of local nasal disease or haematogenous spread are present in what proportion of cats with cryptococcosis.
a. 5%
b. 10%
c. 15%
d. 20%
D
In dogs and cats with cryptococcus lameness can be observed as a clinical sign, what is the underlying cause for this
a. Osteomyelitis
b. Secondary IMPA
c. Septic arthritis
d. Ulcerative cutaneous nodules
A
Dogs infected with cryptococcus are more likely than cats to have disseminated disease, what proportion of infected dogs had multiple organ systems involved?
a. 60%
b. 70%
c. 80%
d. 90%
C
and up to 75% of dogs have neurological signs
In dogs infected with cryptococcus, cryptococcal organisms can be seen in up to what percentage of CSF samples.
a. 30%
b. 50%
c. 70%
d. 90%
D - Note: CSF sampling can cause acute increased in ICP + acute decompensation
Cryptococcus yeasts can be identified using cytology or histopathology, typically seen as a stained cell surrounded by a non-staining capsule. What is the sensitivity for detection of organisms on cytological examination
a. 25-50%
b. 33-66%
c. 50-75%
d. 66-99%
C
Cryptococcal antigen Latex agglutination System (CALAS or LCAT) is highly sensitive (95-100%) and specific (100%) for diagnosing cryptococcosis in cats, however false positives can occur with titres up to what proportion?
a. 1:2
b. 1:20
c. 1:200
d. 1:2000
C
Following treatment what reduction in CALAS titre in the first 2 months of therapy indicates a positive response?
a. 2-fold
b. 4-fold
c. 6-fold
d. 8-fold
B
How long should treatment be continued for cryptococcosis beyond resolution of clinical signs and negative CALAS?
a. 2 weeks
b. 1 month
c. 6 weeks
d. 2 months
D
How frequently should repeat LCAT be performed following discontinuation of therapy for cryptococcosis to monitor for early relapse?
a. Every 3-6 months for 1 year
b. Every 3-6 months for 2 years
c. Every 6-12 months for 2 years
d. Every 6-12 months for 4 years
B
Relapse typically occurs in first 2 year but up to 10 years
