Chapter 3: Folding, Function, and Structure

Question 1

folding tends to be _____

Answer 1

spontaneous

Question 2

hydrophobic interactions drive proteins to _____ such that their _____ R-groups coalesce in the interior, which increases _____ of the surrounding water

Answer 2

fold, nonpolar, entropy

Question 3

a folded molecule has less _____ _____ and is thus more _____ than an unfolded molecule

Answer 3

potential energy, stable

Question 4

most proteins are _____ and _____ when they are not actively performing that function

Answer 4

flexible, dynamic

Question 5

Since the _____ of a protein is dependent on its _____, controlling when or where it is folded into its active shape will regulate its activity

Answer 5

function, shape

Question 6

Prions

Answer 6

normal proteins can be induced to fold into infectious, disease-causing agents

Question 7

prions are an example of how a protein’s _____ depends on its _____ as well as how the final shape of a protein depends on _____!

Answer 7

function, shape, folding