Chapter 29

Question 1

Enlarged lymph nodes

Answer 1

Lymphadenopathy

Question 2

Lower than normal neutrophil count in the blood

Answer 2

Neutropenia

Question 3

Lower than normal blood count of WBC, RBC, and platelets

Answer 3

Pancytopenia

Question 4

Higher than normal WBC count

Answer 4

Leukocytosis

Question 5

Lower than normal WBC count

Answer 5

Leukopenia

Question 6

Higher than normal blood counts of neutrophils, eosinophils, and basophils

Answer 6

Granulocytosis

Question 7

Lower than normal blood counts of neutrophils, eosinophils, and basophils

Answer 7

Granulocytopenia

Question 8

Complete absence of neutrophils, eosinophils, and basophils in the blood

Answer 8

Agranulocytosis

Question 9

Most common causes of eosinophilia

Answer 9

Parasites, toxic foregin particles, and hypersensitivity reactions

Question 10

Monocytosis occurs during the … phase of inflammation

Answer 10

Late

Question 11

Neutrophilia occurs during the … phase of inflammation

Answer 11

Early

Question 12

All types of leukemia are characterized by uncontrolled … of WBC in the … that thereby … the amount and function of erythrocytrs and platelets

Answer 12

Production, bone marrow, decreases

Question 13

May occur pathologically or normally in response to physiological stressors

Answer 13

Leukocytosis

Question 14

Occurs only pathologically

Answer 14

Leukopenia

Question 15

… lymphadenopathy indicates drainage from areas of inflammation

Answer 15

Localized

Question 16

… lymphadenopathy usually indicates a malignant or nonmalignant disease

Answer 16

Generalized

Question 17

Leukemia or lymphoma that has the term lymphoblastic in its name, the malignant cells are …

Answer 17

Immature

Question 18

Persons who have thrombocytopenia have a higher increased risk for … although the other event also may occur

Answer 18

Clotting

Question 19

What does HIT stand for?

Answer 19

Heparin induced thrombocytopenia

Question 20

What does the activated platelet in HIT release?

Answer 20

Platelet factor 4 (PF4)

Question 21

What does PF4 bind to?

Answer 21

Heparin

Question 22

When a person forms HIT antibodies, they react specifically against what?

Answer 22

PF4 heparin complex

Question 23

After HIT antibodies bind to PF4 heparin complex, what mechanism causes more platelets to become activated, causing more clotting?

Answer 23

The Fc end of the antibodies binds to platelet Fc receptors, activating the platelets, which release substances that promote clotting

Question 24

What causes the thrombocytopenia in HIT?

Answer 24

Platelet number decreases because of microclots, extension of previous clots, or formation of new clots, all of which use up platelets

Question 25

Cancers of blood forming cells

Answer 25

Leukemia

Question 26

Cancer of lymphatic tissue

Answer 26

Lymphoma

Question 27

Arises from the lymphoid cell line that normally produces B and T lymphocytes and natural killer celld

Answer 27

Lymphocytic leukemia

Question 28

Arises from the myeloid cell line that normally produces granulocytes, monocytes, erythrocytes, and platelets

Answer 28

Myelogenous leukemia

Question 29

Enlargement of the spleen

Answer 29

Splenomegaly

Question 30

Overactivity of the spleen caused by splenomegaly

Answer 30

Hypersplenism

Question 31

Composed primarily of platelet aggregates held together by strands of fibrin

Answer 31

Arterial thrombi

Question 32

Compose primarily of erythrocytrs, greater amounts of fibrin, and fewer platelets

Answer 32

Venous thrombi

Question 33

Autoantibody against plasma membrane components that causes hypercoagulability by binding to platelets and endothelial cells

Answer 33

Antiphospholipid antibody

Question 34

Abnormal antibody released by malignant plasma cells in multiple myeloma

Answer 34

M protein

Question 35

Genetic mutation that causes hypercoagulability by allowing activated clotting factor Va to remain longer in the blood

Answer 35

Factor V Leiden

Question 36

Mutant tyrosine kinase that drives cell proliferation and survival in some types of leukemia

Answer 36

BCR-ABL1 Variant oncoprotein

Question 37

Genetic translocation between chromosome 9 and 22 that creates a mutant protein implicsted in CML and other types of leukemia

Answer 37

Philadelphia chromosome

Question 38

Infectious mononucleosis is an acute infection of ... lymphocytes commonly caused by ....

Answer 38

B, Epstein -barr virus

Question 39

Typical clinical manifestations of Mono include:

Answer 39

Pharyngitis, fever, cervical lymphadenopathy

Question 40

In Africa ... lymphoma, a rapidly growing B lymphocyte tumor is found....

Answer 40

Burkitt, jaw and facial bones of children

Question 41

Burkitt lymphoma is associated eith what virus?

Answer 41

Epstein-Barr

Question 42

AML stands for

Answer 42

Acute myelogenous leukemia

Question 43

CLL stands for

Answer 43

Chronic lymphocytic leukemia

Question 44

Leukopemia creates increased risk for ....

Answer 44

Infection

Question 45

Hypercalcemia and bone lesions are characteristic of ...

Answer 45

Multiple myeloma

Question 46

In multiple myeloma malignant cells reside in the ... not the ...

Answer 46

Bone marrow, circulating blood

Question 47

... disorder indicates that leukemias are considered to be the product of a mutated progenitor cell that replicates itself uncontrollably

Answer 47

Clonal

Question 48

Bone marrow depression of acute leukemia causes ... due to lack of erythrocytes, fever from ... due to lack of leukocytes, and ... due to lack of platelets

Answer 48

Fatigue, infection, bleeding

Question 49

Splenomegaly secondary to infection in the body increases the risk for spleen ... from blunt trauma

Answer 49

Rupture