Chapter 25-26 Flashcards

1
Q

What hormones are secreted from the anterior pituitary?

A

growth hormone, thyroid-stimulating hormone, adrenocorticotropic hormone, follicle-stimulating hormone, luteinizing hormone

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2
Q

What hormones are secreted from the posterior pituitary?

A

vasopressin and oxytocin

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3
Q

What hormones does the thyroid secrete?

A

thyroxine (T4) and trilodothyronine (T3)

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4
Q

Hyperthyroidism

A

high thyroid hormones

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5
Q

Symptoms of Hyperthyroidism

A

nervousness, thin skin/hair, weight loss, heat intolerance

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6
Q

Hypothyroidism

A

low thyroid hormones

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7
Q

Symptoms of Hypothyroidism

A

fatigue, poor memory, weight gain, cold intolerance

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8
Q

Medication used to treat hyperthyroidism

A

methimazole, propylthiouracil

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9
Q

Medication used to treat hypothyroidism

A

lecothyroxine

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10
Q

How does hyperthyroidism medication work?

A

inhibit synthesis of thyroid hormones

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11
Q

How does hypothyroidism medication work?

A

provides thyroid hormones (T3/T4)

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12
Q

Adverse effects of hyperthyroidism medication

A

fever, rash, low blood cell counts, hypothyroidism

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13
Q

Adverse effects of hypothyroidism medication

A

hyperthyroidism, osteoporosis, coronary artery disease

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14
Q

Hormones secreted by the pancreas

A

glucagon and insulin

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15
Q

How do hormones secreted by the pancreas affect the body?

A

increase or decrease glucose levels in the blood

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16
Q

Differences between type 1 and 2 diabetes

A

type 1 - autoimmune disorder destroys beta cells

type 2- insulin resistance

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17
Q

Complications of diabetes

A

nephropathy, neuropathy, retinopathy, impaired healing

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18
Q

How does metformin work?

A

promote glucose uptake by cells, decrease glucose production by liver, slow glucose absorption

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19
Q

Adverse effects of metformin

A

weight loss, GI upset, diarrhea, lactic acidosis in renal failure

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20
Q

Contraindications of metformin

A

type 1 diabetes, renal failure

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21
Q

Sulfonylureas common medications

A

glipizide, glyburide, glimepride

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22
Q

Adverse effects of sulfonylureas

A

hypoglycemia, weight gain, dizziness, loss of efficacy with further beta cell destruction

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23
Q

Contraindications of sulfonylureas

A

type 1 diabetes and renal elimination

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24
Q

Thiazolidindiones common medications

A

pioglitazone

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25
Q

Adverse effects of thiazolidindiones

A

hypoglycemia, edema, heart failure, factures, weight gain

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26
Q

Contraindications of thiazolidiones

A

heart failure

27
Q

Dipeptidyl peptidase inhibitors (DPP)

A

sitagliptin

28
Q

Mechanism of DPP

A

inhibit DPP to increase insulin release and decrease glucagon secretion

29
Q

Mechanism of sulfonylureas

A

increase insulin secretion from beta cells

30
Q

Mechanism of thiazolidinediones

A

improve insulin sensitivity

31
Q

Adverse effects of DPP

A

peripheral edema, hypoglycemia, diarrhea or constipation, weight gain

32
Q

Contraindications of DPP

A

type 1 diabetes, reduce dose with renal dysfunction

33
Q

Common rapid-acting insulins

A

lispro and aspart

34
Q

Lispro brand name

A

Humalog

35
Q

Aspart brand name

A

Novolog

36
Q

Common long-acting insulins

A

glargine

37
Q

Glargine brand name

A

lantus

38
Q

Adverse effects of insulin

A

hypoglycemia

39
Q

Contraindications of insulin

A

hypoglycemia

40
Q

How do you monitor diabetes therapy?

A

blood glucose testing

41
Q

What hormones are secreted by the adrenal glands?

A

stimulated by ACTH and produce corticosteroids

42
Q

What do corticosteroids do?

A

anti-inflammatory, increase glucose, increase blood pressure

43
Q

Adverse effects of corticosteroids

A

insomnia, hypertension, behavioral changes, stomach ulcers, increased appetite, diabetes, osteoporosis, infections, edmia

44
Q

Contraindications of corticosteroids

A

ulcers, severe infections, psychoses, diabetes

45
Q

Common corticosteroids name ending

A

end in -one

46
Q

What part of the male reproductive system produces sperm?

A

testes

47
Q

Types of hormones the male reproductive system secretes

A

testosterone

48
Q

Hypogonadism

A

decreased sperm or testosterone production from testes

49
Q

Symptoms of Hypogonadism

A

decreased vigor/libido, depressed mood, decreased muscle mass/body hair, decrease size of testes, infertility

50
Q

Medication used to treat hypogonadism

A

testosterone replacement

51
Q

Common side effects of androgens

A

pain at injection site/itching after topical application, gynecomasta, acne, prostate growth/prostate cancer, hepatotoxicity

52
Q

Contraindications to androgens

A

prostate cancer, liver disease, pregnancy

53
Q

What part of the female reproductive system produces eggs?

A

ovaries

54
Q

What types of hormones the female reproductive system secretes?

A

estrogens and progesterone

55
Q

Common estrogens

A

estradiol, conjugates estrogens (Premarin)

-estra in name

56
Q

Adverse effects of estrogens

A

changes in libido, edema, breast enlargement, cardiovascular disease, stroke, clots, dementia

57
Q

Contraindications of estrogens

A

breast cancer, clots, pregnancy, breastfeeding

58
Q

Common progestins

A

medroxyprogesterone, norethindone, progesterone

59
Q

Adverse effects of progestins

A

weight gain, clotting, breakthrough bleeding, cycle irregularity

60
Q

Contraindications of progestins

A

pregnancy, breastfeeding, active clots

61
Q

Mechanism of contraception

A
  • inhibit release of gonadotropin releasing hormone
  • pituitary doesn’t release FSH/LH
  • ovulation doesn’t occur
  • uterus wall thins
  • uterine mucus becomes too thick for sperm
62
Q

Adverse effects of contraception

A

nausea, abdominal pain, weight gain, cycle irregularities, clotting

63
Q

Contraindications of contraception

A

pregnancy, clotting

64
Q

Effects of oxytocin

A

similar to oxytocin released by posterior pituitary
increases uterine smooth muscle contraction
promote milk ejection from mammary glands