Chapter 24 - The Digestive System Flashcards
The digestive system consists of what two things?
The gastrointestinal (GI) & accessory digestive organs
The GI tract portion of the digestive system is a continuous tube that includes? (6)
Mouth, pharynx, esophagus, stomach, small intestine, large intestine
The accessory organs of the digestive system include? (6)
Teeth, tongue, salivary glands, liver, gallbladder, pancreas
Name the basic processes of the digestive system? (6)
Ingestion, secretion, mixing and propulsion, digestion, absorption, defecation
Involved in eating; is the taking of foods and liquids into the mouth
Ingestion
Is the release of water, acids, enzymes, etc into the digestive tract
Secretion
Churning and movement of food through the GI tract
mixing and propulsion
The mechanical and chemical breakdown of food
Digestion
Passage of digested products from the GI tract into the blood and lymph
Absorption
The elimination of feces from the GI tract
Defecation
Made up of wastes, indigestible substances, bacteria, sloughed-off cells
Feces
The wall of the GI tract from the lower esophagus to the anal canal has the same basic 4-layered arrangement of tissues. They are?
Mucosa, submucosa, muscularis, serosa
This is the inner lining of the GI tract?
Mucosa
The mucosa is a mucus membrane that is composed of what 3 things?
Epithelium, lamina propria, muscularis mucosae
What is the epithelium of the mucosa? It is in contact with?
A layer of cells which is in contact with the contents of the GI tract
What is the lamina propria if the mucosa?
A layer of connective tissue
What is the muscularis mucosae of the mucosa?
A thin layer of smooth muscle
The wall of the stomach is composed of?
The same 4 layers as most of the rest of the GI tract with a few differences.
The muscularis in the body of the stomach has how many layers of smooth muscle? As opposed to? The layers are?
3 as opposed to 2 as in the intestines and rest of the stomach / an oblique layer, middle circular layer, outer longitudinal layer
The epithelium of the stomach extends deep down into the mucosa forming channels called?
Gastric pits
Some of the epithelial cells of the stomach secret mucus and are called? The mucus helps to?
Surface mucous cells / protect the stomach from the acidic pH of stomach acid
As the bottom of gastric pits in the stomach, there are these which are composed of secretory cells.
Gastric gland
The gastric glands secret substances into? These substances eventually?
Into the gastric pits. They eventually reach the lumen of the stomach.
The gastric glands contain 4 types of cells. They are?
Mucous neck cells, chief cells, parietal cells, g cells
A type of gastric gland cell that secretes mucus along with the surface mucous cells.
Mucous neck cells
A type of gastric gland cell that secrete pepsinogen and gastric lipase
Chief cells
A type of gastric gland cell that produces intrinsic factor (needed for the absorption of vitamin b12) and hydrochloric acid.
Parietal cells
A type of gastric gland cell that secretes the hormone gastrin into the bloodstream.
G cells
This helps regulate stomach secretions and motility (increases both)
Gastrin
Stomach acid aka?
Gastric juice
This is composed of the secretions of the mucous, parietal, and chief cells
Gastric juice (stomach acid)
How many quarts of gastric juice is secreted each day? What is the pH level?
2-3 quarts / 2 (strongly acidic)
How long does the passage of food from the mouth usually take?
Seconds
Once food enters the stomach, what happens?
Starch digestion by salivary amylase continues for awhile.
After starch digestion y salivary amylase, food becomes mixed with? What happens to the salivary amylase?
Gastric juice and liquified to form chyme and salivary amylase is inactivated.
Hydrochloric acid in the gastric juice kills many microbes in the food and causes?
The conversion of the inactive enzyme pepsinogen into the active version of pepsin.
This digests proteins by breaking bonds between amino acids
Pepsin
This is secreted by chief cells in its inactive form to prevent it from digesting proteins in the cells.
Pepsin
This is secreted by chief cells and digests triglycerides in fat.
Gastric lipase
Not much of this occurs in the stomach? Only for?
Absorption / water, alcohol,certain drugs (aspirin) and a few other substances
After 2-4 hours what has the stomach done?
Emptied contents into the duodenum
A retroperitoneal accessory digestive organ that is about 5-6 inches long and lies posterior to the stomach.
Pancreas
Pancreatic juices passes to the duodenum through what 2 ducts?
Pancreatic duct (duct of Wirsung) and accessory duct (duct of Santorini)
The pancreatic duct generally joins? It then enters the duodenum as a common duct called?
Common bile duct from the liver / hepatopancreatic ampulla (ampulla of Vater)
The accessory duct empties into?
The duodenum about an inch superior to the hepatopancreatic
The pancreas is made up of what two main types of cells?
Acini & Pancreatic islets
99% of the pancreatic cells are of this type. They secrete pancreatic juice
Acini
1% of pancreatic cells are of this type. They are endocrine cells that secrete hormones.
Pancreatic islets (islets of Langerhans)
Ow much pancreatic juice does the pancreas produce each day?
1.2 - 1.5 quarts.
This substance is a clear, colorless liquid composed of water, some salts, sodium bicarbonate, and several enzymes.
Pancreatic juice.
The sodium bicarbonate gives pancreatic juice a pH of about? This buffers gastric juice and stops. What?
7.1 - 8.2 (slightly alkaline) / stops the action of pepsin.
Pancreatic amylase, trypsin, chymotrypsin, carboxypeptidase, pancreatic lipase, ribonuclease, deoxyribonuclease are enzymes found in?
Pancreatic juice
This digests starch
Pancreatic amylase
These pancreatic digestive juice enzymes digest protein. (3)
Trypsin, chymotrypsin, carboxypeptidase
This digest juice enzymes digest triglycerides
Pancreatic lipase
This pancreatic digestive juice enzyme digests RNA
Ribonuclease
This pancreatic digestive juice enzyme digests DNA
Deoxyribonuclease
To prevent them from digesting proteins in the pancreas, these protein digesting enzymes are produced in an inactive form which are? (3)
Trypsinogen, chymotrypsingogen, procarboxypeptidase
This is the inactive form of trypsin
Trypsinogen
This is the inactive form of chymotrypsin
Chymotrypsinogen
This is the inactive form of carboxypeptidase
Procarboxypeptidase
The primary hormones secreted by the pancreas are?
Insulin and glucagon
Insulin is secreted by what cells?
Beta cells
Glucagon is secreted by?
Alpha cells
This raises blood glucose levels?
Glucagon
This lowers blood glucose levels.
Insulin
Low blood glucose levels in a person is termed?
Hypoglycemia
Hypoglycemia stimulate?
The secretion of glucagon
Glucagon targets cells of the? This causes them to convert?
Liver / glycogen into glucose
After glucagon is converted into glucose, the glucose is released into where? This causes?
Into the blood / blood glucose levels to rise
High blood glucose levels
Hyperglycemia
Hyperglycemia inhibits? It stimulates?
The release of glucagon and stimulates the release of insulin.
Insulin acts on? Increasing?
Various body cells increasing the rate at which glucose moves into them.
Most glucose that enters the liver is converted into?
Glycogen
This inhibits the release of both insulin and glucagon.
Somatostatin
Insulin acting on various body cells and glucose entering the liver causes blood glucose levels to?
Decrease
The liver and gallbladder are two accessory digestive organs involved with the secretion of?
Bile
This emulsifies liquids before they are digested.
Bile
The liver is divided into two lobes by the?
Falciform ligament
This suspends the liver in the abdominal cavity?
Falciform ligament
The lobes of the liver are made up of?
Lobules
Liver cells within the lobules that secrete bile
Hepatocytes
The bile leaves the lobules of the liver through small ducts that eventually merge to form these which exit the right and left lobes.
Right and left hepatic ducts
The right and left hepatic ducts united and exit the liver as?
Common hepatic duct
The common hepatic duct joins this duct from the gallbladder? The form?
Cystic duct / common bile duct
The main function of the gallbladder is?
To store and concentrate bile produced by the liver until it is needed by the small intestine.
The wall of the gallbladder consists of what kind of muscle? It contracts and causes?
Smooth / the ejection of stored bile into the cystic duct
Hepatocytes secrete how much bile per day?
1 quart
This is a yellow, brownish, or olive-green liquid?
Bile
Bile has a pH of? It consists mostly of? (6)
7.6 - 8.6 / water, bile salts, cholesterol, lecithin, bile pigments and several ions
The main bile pigment is?
Bilirubin
As old red blood cells are phagocytized, what is formed?
Iron, globin (protein), and bilirubin (derived from heme) are formed.
After bilirubin is formed from the phagocytized red blood cells, the bilirubin is secreted into?
Bile and eventually broken down in the small intestine.
One of the products of the breakdown of bilirubin in bile is?
Stercoblin
This gives feces its normal brown color
Stercoblin
These help to emulsify, or breakdown, large lipid molecules so that enzymes such as pancreatic lipase can digest them.
Bile salts
A yellowish coloration of the whites of the eyes and the skin due to a build up of bilirubin
Jaundice
Jaundice can occur when?
The liver does not function properly to eliminate bilirubin
The liver receives blood from these two sources.
Hepatic artery and hepatic portal vein.
The hepatic artery carries what kind of blood?
Oxygenated
The hepatic portal vein carries what kind of blood? It contains?
Deoxygenated blood containing newly absorbed nutrients, drugs, and microbes and toxins from the GI tract.
Branches of the hepatic artery and the hepatic portal vein carry blood into liver?
Sinusoids
Capillaries that carry oxygen, nutrients, and toxic cub stances to hepatocytes
Sinusoids
These carry deoxygenated blood away from the liver
Hepatic veins
the 3 regions of the small intestine
duodenum, jejunum, ileum
The first and shortest region of the small intestine. About 10 inches long.
Duodenum
The second region of the small intestine. About 3 ft long.
Jejunum
The final and longest region of the small intestine. About 6 ft long.
ileum
This is at the junction of the ileum and the large intestine.
ileocecal sphincter
The wall of the small intestine is composed of?
The same 4 layers that make up most of the rest of the digestive tract.
The epithelium of the mucosa in the small intestine contains these cells what 2 cells?
absorptive and goblet cells
cells which absorb nutrients and found in the small intestine
absorptive cells
Cells in the small intestine which secret mucus
goblet cells
The functions of the liver (9)
carbohydrate metabolism, lipid metabolism, protein metabolism, processing of drugs and hormones, excretion of bilirubin, synthesis of bile salts, storage, phagocytosis, activation of vitamin D
What does the carbohydrate metabolism function of the liver do?
helps to maintain a normal blood glucose level.