Chapter 23 Digestive System Flashcards

1
Q

Digestive System

A
  • Two groups of organs
  • Alimentary Canal (Gastrointestinal GI tract)
    • mouth to anus
    • digests food/ absorbs fragments
    • Mouth, pharynx, esophagous, stomach, small intestine, large intesitn
  • Accesory Digestive organs
    • Teeth, tounge, gallbladder, digestive glands
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2
Q

Digestive Processes

A
  • Ingestion) taking food into digestive tract (eating)
  • Propulsion) moves food through alimentary canal
    • swallowing) Initated voluntary
    • periatalsis) Involuntary swallowing
  • Mechanincal breakdown) chewing, mixing food with saliva, churning
    • Segmentation) local constrictions of small intestine to mix food with digestive juices. makes absorption more efficent.
  • Digestion) Catabolic reation where enzymes secreted into lumen brak down food
  • Absorption) Passage of Digested end products from the lumen of GI tract into blood
  • Defication) elimination of indesgtibale substances from the body
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3
Q

Peritonium and Peritoneal Cavity

A
  • Peritoneum) serous membrane of abdominal cavity
    • Visceral Peritoneum) on external surface of most digestive organs
    • Parietal Peritoneum) lines the body wall
  • Peritoneal cavity) between two peritoneums
    • fluid lubricates mobile organs
  • Mesentary) Duble layer of peritoneusm
    • sheet of two membranes fused back to back
    • extends to digestive organs from the body wall
    • Routes vesels and nerves to digestive organs
    • Holds organs in place. Stores fat
    • Mostly found dorsally, some ventral mesentary
  • Retroperitoneal Organs) Posterior to peritoneum
    • most of the pancreas and duodenum and parts of large intestine
  • Intraperitoneal Organs) Surrounded by peritoneum
    • Stomach keeps its mesentary
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4
Q

Peritonitis

A
  • Inflammation of the peritoneum
  • causes) piercing abdominal wound, ulcer, ruptured apendix
  • Treatment) removal of debris and antibiotice
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5
Q

Histology of the Alimentary Canal) Mucosa

A
  • Mucosa) moist epithelial membrane that lines alimentary canal lumen from mouth to anus
    • Secretes mucus, digestive enzymes and hormones
    • Absorbs end products of digestion
    • Protects against infectious desiese
  • Three Sublayers
  • Epithelium) Simple columnar epitheliam rich in mucus- secreting cells
    • stratified squamous epithelium in mouth, esophagous, and anus
    • Mucus) Protects digestive organs from enzymes and eases food passage
  • Lamina Propria) Loose areolar connective tissue
    • Capalries nurish epithelium and absorb digestion nutrients
    • Lymphoid Follicles) defend against microoorganisms
  • Muscularis Muscosae) Layer of smooth muscle cell
    • provide local movemnts of mucosa
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6
Q

Histology of the Alimentary Canal) Submucosa

A
  • Areolar connective tissue
  • Blood and lymphatic vessels, lymphoid follicles and nerve plexus.
  • Abundent elastic fibers enable stomach to regain its normal shape after temporarily storing a large meal
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7
Q

Histology of the Alimentary Canal) Muscularis Externa

A
  • Responsible for Segmentation and Peristalsis
    • Inner circular and outer longitudinal layers
  • Sphincters) circular layer thickents in some areas
  • Myenteric nerve plexis located bettween two muscle layers
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8
Q

Serosa

A
  • Outermoast layer of intraperitonal organs is Visceral Peritoium
    • Areolar CT covered with moesothelium (single layer of squamous epithelial cells)
  • Serosa is replaced by fibrous dense, CT called Adventitia in esophagus
  • Retropreitoneal Organs) have both an adventitia and serosa
    • adventita) faces dorsal body wall
    • Serosa) faces peritoneal cavity
      *
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9
Q

Blood Supply) Splanchic Circulation

A
  • Splanchnic Circulation) arteries that branch off abdominal aorta to serve digestive organs and hepatic portal circulation
    • Aterial suply the branches of celiac trunk that serve spleen liver and stomach and the mesentaric aterties which serve digestive system (recive one quarter of cardiac output)
  • Hepatic Portal Circulation
    • Drains nutrient-rich blood from digestive organs
    • Delivers to Liver for processing
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10
Q

Enteric Nervous System

A
  • Entric Nervous System) GI trac’ts own nervous system
    • conists of over 100 million nuerons
    • Steffed by enteric nuersons
  • Two major Intresnsic Nervous Plexuses (ganglia ocnnected via unmyelnated tracts) found in the wall of the GI canal
  • Submucosal Nerve Plexus) occupies submucosa
  • Myerntric Nerve Plexus) lies between circular and longitudal mucle laters of muscularis externa
    • Myenteric = Intestinal Muscle
  • Entrict Neuerons control GI tract mobility
  • Short Reflex arcs) Respond to stimuli inside GI tract
    • controls segmentation and peristalsis
    • involves pacemaker cells
    • “Gut Brain” ) local intresnsic nerve plexus
  • Long Reflex Arcs) Responds to stimuli inside or outside the GI tract
    • Involve CNS centers and autnomic nerves
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11
Q

Concepts of Regulating Digestive Activity

A
  • Provoked by a range of mechanical and chemical stimuli
    • Receptors are in wall of GI tract organs
    • Reponds to stretch, changes in osmolality and ph, presense of substrate and end products of digestion
  • Effectors of Digestive activity are smooth muscle and glands
    • Initate reflexes
    • Activate/ inhibit digestive glands
    • stimulate smooth muscle to mix and move lumen contents
  • Nuerons. (intrinsic and extrinsic) and hormones control activity
    • Nuerons) control digestive system intresnsicly and extrensically
    • Hormones) from cells in stomach/ small intestine stimulare tatget cells or organs
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12
Q

Mouth

A
  • Oral (buccal) cavity
    • bounded by lips, cheeks, palate and tounge
    • Lined with statified squamous epithelium
  • Lips and Cheeks
    • Contain obicularic oris and buccinator muscles
    • Vestible (“Porch”) space betwen gums and lip
    • Oral cavity proper) area within teeth and gums
    • Labial Frenulum) median attachment of each lip to the gum
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13
Q

Palate

A
  • Hard Palate) Palatine bones and palatine process of maxillae
    • forms a ridgid surface which the tounge forces food agaisnt while chewing
    • Raphe) midlle rigdge which is slightly corrugated
  • Soft Palate) fold formed mostly of skeletal muscle
    • closes nasopharynx when swallowing
    • Uvula projects downward from its free edge
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14
Q

Tounge

A
  • Skeletal Mucslce; Functions Include
    • Repositioning/ mixing food during chewing
    • Formation of bolus
    • Initation of swallowing, speech and taste
  • Intresnic Muscles) change shape of tounge as needed
  • Extrensic muscles) change tounges position
  • Lingual frenulum) attachemnt to the floor
  • Papillae) holds tate buds
    • Filifrom) whitish, give tounge rougness and provide friction
    • Fungiform) reddish, scattered over tounge, contain taste buds
    • Circumvallate (vallate) v shaped row on back of tounge; contains buds
    • Folitate) on lateral aspects of the tounge
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15
Q

Salivary Glands

A
  • Extrinsic Salivary Glands) PRiduce saliva; lie outside oral cavity
    • Partoid, Sumbandibular, Sublingual
  • Minor/ Intresnsic Salivary glands) scattered throuought oral cavuty
    • Buccal glands and others
  • Function of Saliva
    • cleans mouth, dissolves food chemicals for tatste, moistens food, and begins to break down starch via enzyme amylase
  • Partoid Gland) major salivary glands
    • anterior to ear; ecternal to masseter mucle
    • Duct opens itno vestible next to second upper molar
  • Submandibular
    • Medial to body of mandible
    • Duct opens at base of lungual frenulum
  • Sublingual Gland
    • Anterior to submandibular gland under tounge
    • Opens via 10-20 ducts into floor of the mouts
  • Two typed of silvary gland cell secretions
    • Serous cells) watery, enxymes, ions, bit of mucin
    • Mucous cells) mucus
  • 97-99.5 percent water, slightly acidic
  • 1500 ml/day
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16
Q

Teeth

A
  • Tear and grind food for digestion
    • fully formed by age 21
  • 20 Decidous teeth (decid = falling off)
    • baby teeth
    • Roots reabsorb when teeth fall out
  • 32 Permanent Teeth
    • All but third molars in by end of adolescense
    • third molars ( widsom teeth) may or may not erupt
  • Incisors) chisel shaped for cutting
  • Canines) fang like teeth that tear or pierce
  • Premolars (bicuspids) Broad corwn, Rounded cusps- grind/grush
  • Molars) Broad corwn, Rounded cusps - best grinders
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17
Q

Tooth Structure

A
  • Crown) exposed part above gingiva (gum)
    • covered by enamal (hardest substance in body)
    • Enamal-producing cells degenrate when tooth erupts
  • Root) Portion embed in jawbone
  • Cement) calcified connective tissue
  • Peridontal Ligament) Anchors tooth in bony socket
    • Gomphosis) tooth joint
  • Ginvival sulcus) groove where gums boarders tooth
  • Dentin) bonelike material under enamal
  • Pulp cavity) surrounded by dentin, Contains pult
  • Root canal) where pulp cavity extends to root
  • Apical Foramen) at proximal end of the root
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18
Q

Tooth and Gum Disease

A
  • Dental Caries (rottenness)(cavities) demineralization of enamal and entin from bacterial action
    • dental plaque) adheres to teeth
    • acid from bacteria dissolvles calcium salts
    • Enzymes from bacteria digest organic matter
  • Gingivits) plaque calcifies to from calculus (tarter)
    • Calculus dirupts seal between gingicae and teeth
    • Anerobic bacteria infects gums
  • Peridontitis or Periodontal Disease (neglected gingivitis)
    • Immune cells destroy peridontal ligament and dissolve bone
    • Possible tooth loss
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19
Q

Digestive Processes) Mouth

A
  • Ingestion (eating)
  • Mechanical Digestion (Mastication) (chewing)
    • Cheeks and closed lips hold food between teeth
    • Tounge mixes food with saliva; compacts food into bolus
    • teeth cut and grind
  • Propulsion (Deglutition or swallowing)
  • Chemical digestion) salivary amulase and lingual lipase
    • some drugs can be absorbed into mouth
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20
Q

Pharynx

A
  • Food passes from mouth > oropharynx > laryngopharynx
    • Allows passage of food and air
    • Statified squamous eitheliam
    • Pharyngeal Constrictors) encircle the wall
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21
Q

Esophagus

A
  • Flat muscular tube from laryngopharynx to stomach
  • Pierces diaphragm at esophageal hiatus
  • Joins stomach at cardial oriface
  • Gastrophageal (cardiac) sphincter) surrounds cardial orifice
  • Esophegial mucosa
    • Contains stratified squamous epithelium
    • changes to simple columar at the stomach
  • Esophageal glands in submucosa) secrete mucus to aid in bolus movment
  • Adventiti is CT
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22
Q

Deglutition (swallowing)

A
  • Involves tounge, soft palate, pharynx, and esophagus
    • 22 muscle groups help with swallowing
  • Buccal Phase
    • Occurs in mouth, is voluntary ends when food leaves the mouth
  • Pharyngeal-esophageal pase
    • Involuntary- primarrly vagus nerervr
    • Controlled by swalllowing center in the medulla and pons
    • Once food enters the pharynxm respiration momnetarily inhibited
    • Solid food passes from oropgaynx to the stomach.
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23
Q

Stomach) Gross anatomy

A
  • Upper left Quadrant is Temporary storage
    • chemical digestion of Bolus. Changes to Chyme
  • Rugae) When empty; stomcach collapses inward and mucosa and submucosa wrinkle into large, longutidinal folds called Rugae
  • Cardia) near the heart
    • surrounds cardial oriface where food enters
  • Fundus) dome shaped region beneath diaphragm
  • Body) midportion
  • Pyloric Part) Inferior part of stomach
    • Plyoric Antrum) superior portion, leads into Plyoric canal
    • Continuious with duodenum through the plyoric valvue (Sphincter).
  • Greater Curvature) Convex Lateral Surface
  • Lesser Curvature) concave medial surface
  • Two messentaries, called Omenta anchor the stomach
    • Lesser Omentum) Liver to lesser curvature
    • Greater omentum) drapes inferiorly from greater curvature > over large intestine > attaches to spleen and transcerse colon (transverse mesocolon)
  • Innervation
    • Sympatetic) Thoracic splabchnic nerves through celiac ganglion
    • Parasympatic) vagus nerve
  • Blood Supply
    • Cliac Trunk) gastric and splenic branches
    • Veins) Hepatic Portal system
24
Q

Stomach) Microscopic Anatomy

A
  • Contains normal Tunics of Alamanery canal (Mucosa, Submucosa, Muscularis Externa, Serosa) but the Mucosa and Muscularis Externa are diffrent
  • Muscularis Externa
    • Three layers of smooth muscle instead of two
    • Circular, longitudal, and innermost oblique layer
    • Allows stomach to churn, move, and mix food
  • Mucosa
    • Simple columnar epithelium compsoed of mucous cells
    • Secrete two layer coat of Alkaline mucus
      • surface layer) traps bicarbonate-rich fluid beneath it
    • Contains Gastric Pits that Lead into Gastric Glands
25
Q

Gastic Glands

A
  • Produce Gastric Juice
  • Cell types
    • mucus neck cells, Parietal cells, chief cells, entroendocrine cells
  • Glands in fundus and body produce most of the stomach secretions
  • Prietal Cell Secretions
    • Hydrochloric Acid (HCl) pH 1.5-3.5. Denatures protein, activates pepsin, breaks down plant cell walls, kills bacetia
    • Intrensic factor) glycoproteinen required for B12 absorption
  • Cheif cell secretions
    • Pepsinogen) Inactive form of pepsin activted by HCl and peprsin itself
    • Lipases) digest about 15% of lipids
  • Enteroendocrine cells (“gut endocrine”)
    • secrete chemical messengers
    • Act as paracrines (seratonin and histamine)
    • Somatostatin Hormone) acts as a paracrine
    • Gastrin Hormone) regulates stomach secretion and mobility.
26
Q

Mucosal Barrier

A
  • Harsh digestive enzymes can digest stomach itself but it has mucosal barrier to protect itself
  • three factors
  • Thick layer of bicarbonate-rich mucus
  • Tight Junctions between epithelial cells
    • prevents juice from seeping into tissue
  • Damaged epithelial cells quickly replaced by division of stem cells.
    • Surface cells replaced every 3-6 days
27
Q

Gastritis

A
  • Inflammation caused by anything that breaches mucosal barrier
  • Persistent damage to undelying tissues can cause
    • peptic ulcers, specifically called gastric ulcers when it is stomach wall is eroding. Cause Hemmorage
  • Caused mostly by Helicobacter Pylori Bacteria,
    • NSAID’s, smoking, spicy food, alcohol, coffee or stress also can cuase.
28
Q

Digestive Processes in the Stomach

A
  • Propulsion) Peristalsis
  • Mechanical Breakdown) churning of stomach during peristalsis
  • Digestion
    • Denaturation of protiens by HCl
    • Proteins digested by pesin
      • milk protein is digested by rennin in infants
    • Fat) mostly digested in small intestine byt gastric and lingual lipases help.
  • Absorbtion) not much abosrbed in stomach
    • Secretes Intresnsic Factor for intestinal absption of B12
      • prodices mature red blood cells (pernicious anemia)
29
Q

Regulation of Gastric Secretion

A
  • Gastric mucosa secretes three L of gastric juice a day
  • Nural Control)
    • Vagus nerve stimulation (parasympathetic) > secretion up
    • Sympathetic stimulation > Secretin Down
  • Hormonal control) largly Gastrin
    • Stimulates secretion of acid by stomach and secretion of hormones (gastrin antagonists) by small intestine
    • ACh and Histamine also stimulate pareiteal cells.
30
Q

Three Phases of Gastric Secretion

A
  1. Cephalic (reflex) phase) before food enters the stomach
    • Triggered by aroma, sight, or though of food
    • triggers vagus nerve
  2. Gastric Phase) when food reaches the stomach
    • lasts 3-4 hours; 2/3 of gastric juice release
    • Ditension) activates streach receptors for both short and long term reflxes
    • Protein in stomach > rises pH of gastric content > stimulates gastrin secretion > HCl release.
    • Low ph Inhibits gastrin
  3. Intestinal Phase) partially digested food enters the small intestine
    • Stimulated by food entering the duodenim. Intestinal (enteric) gastrin release stimuates intestinal activity
    • Inhibition) Dissention of the duodenum or presensce of acidic, fatty or chyme all tell stomach to stop (decrease gastric emptying)
31
Q

Enterogastric Reflex and En

A
  • Inhibits acid secretion in the stomach by short and long reflexes
  • Enterogastrones) hormones release by a scattering of enteroendocrine cells in duodenal mucosal epithelium.
    • Secretin and Cholecystokinin (CCK)
    • all inhibit gastric secretion
32
Q

Gastric Contactile Activity

A
  • Peristaltic waves
    • move toward pylorus at a rate of 3 per min; more vigurous near pylorus.
    • each wave squirts 3 ml or less of chyme into the small intestine
    • the rest (~27 or so) is propelled backward where it it mixxed more
      *
33
Q

Refulation of Gastric (stomach) emptying

A
  • Larger meal = faster absorption of liquid componats
    • stomach needs longer to absorb solid compnants
  • As Chyme enters Duodenum
    • receptors repond to streatch and chemical signals
    • Initiates entrogastric reflex and hormonal mechanisms to inhibit secretion and duodenal filling
  • Carb Rich chyme moves quickly through duodenum
  • Fat chyme remains in duodenum 6 hours or more
34
Q

Vomiting (emesis)

A
  • Causesed by
    • Extreme stretching of stomach or intestine
    • Intestinal irritants, e.g., bacterial toxins, excessive alcohol, spicy food, certain drugs
  • Excessive vomiting > dehydration, electrolyte and
    acid-base imbalances (alkalosis)
35
Q

Liver

A
  • Bile Production
    • bile) fat emulsifier that breaks fat into tiny particles
  • Largest Gland in the body
  • Four lobes) left right, cudate and quadreate
  • Lesser Omentum) anchors liver to lesser curvate of the stomach
  • Hepatic artery/ vein enter at porta hepatis
  • Bile leaves the liver through the left and right hepatic ducts
    • fuse to form large common hepatic duct > cystic duct > bile duct in gall bladder
36
Q

Liver Microscopic Anatomy

A
  • Liver Lobules) Structural and functional units
    • Hepatocytes) liver cells. Radiate outward from a centeal vein running longitudallly to axis of the lobule
  • Portal Triad) corner of each lobule
    • Branch of hepatic artery) supplies O2
    • Hepatic Portal Vein) brings in nutrient ruch blood
    • Bile Duct) recives bile from bile canaliculi
  • Liver Sinusoids) behind hepatic plates
    • heavily fenestrated
  • Hepatic/ Stellate macrophages) remove debris and old RBC’s
37
Q

Bile

A
  • Yellow-Green, alkaline solution containing
    • Bile salts) cholesterol dericatives that function in fat digestion and absorption.
    • Bilirubin) cheif bile pigment. Yellow waste from the heme- part of hemoglobin
38
Q

The Gallbladder

A

• Thin-walled muscular sac on inferior surface of liver
• Stores and concentrates bile
• Muscular contractions release bile via cystic duct,
which flows into bile duct

39
Q

Pancreas

A
  • Deep to Greater Curvature of the stomach. Head encircled by Duodenum; tail next to the spleen
  • Produces enzymes that break down all categoreis of food
    • Endocrine) secrerete insulin and glucagon (pancreatic inluts)
    • Exocrine) secrete pancreatic juice (acini and ducts)
  • Zymogen Granules) of acini cells contain digestive Proenzymes
  • Pancreatic Juice) 1200-1500 ml per day
    • Electrolytes (HCO3-)
    • pH 8. Alkaline nutralizes chyme for intestinal enzymes
    • Amlyase (starch) Lipase (lipids) Nucleases (nucleaic acids) Proteases (Proteins; secreted in inactive form to protect pancreas)
    • Trypsinogen > activated trypsinogen > activtaes carboxipeptidase and chymotrypsin.
40
Q

Bile / Pancreatic Secretion into Small Intestine

A
  • Bile Duct (liver) and Main Pancreatic Duct
    • Join a in the wall of Duodenunm at Hepatopancreatic ampulla
    • Opens into Duodnum at Major Duodenal Papillla
    • Controled by Hepatopancratic Spinchter
      • Acessory Pancratic Duct) empties directly into duodenum just proximal to midn duct. Just Pancreeas
41
Q

Regulation of Bile/ Pancreatic Secretion

A
  • Hormonal and Nueral Stimuli both regulate secretion of bile/ Pancreatic juice
  • CCK
    • Stimulated by proteins and Fats in the Chyme
    • Induces secretion of Pancreatic Juice from Acinar cells of pancreas
    • Causes gall bladder constriction
    • Causes Hepatopancratic Sphincter to Relax (release of bile/pancreatic enzymes)
  • Secretin
    • Stimulated by acidic chyme
    • Causes secretion of HCO3- fom duct cells of pancreas
    • Minor stimilus for Bile production
  • Bile
    • Bile Salts returning from enterohepatic circulation stimulate more bile secretion.
  • Vagus Nerve
    • Weakley stimulates pancreas and gallbladder during cephalic and gastric phases.
42
Q

Gross Anatomy of The Small Intestine

A
  • Major Organ of Digestion and Absorption
    • 2-4 m long (7-13ft) Half of the diameter of the large intstine
    • Longest part of alamentary canal
  • Duodenum
    • Mostly a Retroperitonial Organ
    • about 25 cm long (10 in)
  • Jejunum) Extends from duodenum to ileum
    • about 2.5 m (8ft) long
  • Illeum) Joins large intstine at ileocecal valve.
    • about 3.6 m (12ft) long.
  • Fan Shaped Mesentary) supports jejunum and ileum from posterior wall.
  • Innervation
    • Parasympatetic) vagus
    • Sympatetic) Thoracic Splanchnic Nerves
    • Both relayed through superior mesentatic and celiac plexuses’
  • Blood Vessels)
    • Mesentaric Arteries
    • Mesentatic Veins > Hepatic Portal Vein> Liver
43
Q

Modifications of The small intestine for absorption

A
  • Increase surface area of proximal part for nutrient absorption
  • Circular Folds)
    • Permanent folds that force chume to spiral through lumen
    • Slows movment which allows more time for nutrient absorption
  • Vili
    • Fingerlike projections of mucosa
    • Each vilus has a capilary bed and Lacteal (lymphatic) capilary for absorption
  • Microvilli (Brush boarder)
    • Long, cytoplasmic extensions of absorptive cells of mucosa
    • Contain encymes for Carb and Protein digestion (Brush Boarder Enzymes)
44
Q

Histology of Small Intestine Wall

A
  • Intestinal Crypts) Tubular Glands located between the Vili in the mucosa
    • decrease in number the further down the small intestine you go
  • Five Major cell types
  • Enterocytes)
    • Villi) Primary responsibility is absortion in the villi
    • Crypts) they produce intestinal juice which serves as a carrier fluid for absorbing nutritnes
  • Goblet Cells) secrete mucus in villi and crypts
  • Enteroednocrine Cells)
    • secrete Enterogastrones (secretin, Cholecysotokinin)
  • Paneth Cells
    • Located deep in the crypts
    • Secrete antimicrobial agents (defensins and lysozyme)
  • Stem Cells
    • Divide in the bottom of crypts
    • daughter cells differentiate to become all other types of cells
    • most cells migrate up, paneth cells migrate to the bottom of the crypts.
45
Q

Mucosa of Small Intesine

A
  • Mucosa-Associated Lymphoid Tissue (MALT)
    • Included induivudual lymphoid Follicles and Aggregated Lymphoid Nodules (Peyer’s Patches)
    • Peyer’s Patches are more abundent in the distal part of small intestine (more bacteria)
46
Q

Intestinal Juice

A
  • 1-2L Secreted Daily; Major Stimulus for production comes from hypertonic or acidic chyme
  • Slightly alkaline
    • Isotinic with blood plasma (7.35-7.45 pH)
47
Q

Digestion Processes in the Small Intestine

A
  • Chyme from stomach contains partially diegested Carbs, Proteins and undigested Fats
    • spends 3-6 hours in small intestine
    • Most water and all nutrients are absorbed
  • Enymes for digestion
    • Most substances for digestion; bile, enzymes except brush boarder, and bicarbonate ions, are imported from the liver or pancreas
    • If either organ’s function is impeded our ability to digest food goes down.
  • Regulating Chyme Entry
    • Chyme is hypertonic = if a bunch rushes into the duodenum and small intestine it would pull water away from the capalaries of Villi
    • Low pH of chyme must be adjusted and chyme must be well mixed
    • Enterogastric reflex and enterogastrones carfully controls food movement into the small intestine.
48
Q

Mobility of the Small Intestine

A
  • After a meal
    • Small intesine has contracting rings of smooth muscle which simply move the chyme back and forward.
    • Stomach Peristalsis initates these movments
  • Segmentation
    • Most common motion of small intestine; Initated by intrnsic pacemaker cells
    • Mixes/ Moves contents to the end
    • Increased by Parasumpatetic tone
  • Bewteen Meals
    • True Peristalsis occurs only after most nutrients have been absorbed
    • Segmenting movements wane and duodenal mucosa begins to release Motilin
49
Q

Illeocecal Valve Control

A
  • Illeocecal Valve is closed most of the time
  • Two mechanisms cause it to relax and let chyme to the small intesine
  • Gastorieal Reflex
    • Long nueral reflex triggered by stomach activity
    • Increases force of segmentation in ileum and relaxes the valve
  • Gastrin)
    • Hormone released by stomach
    • Increases mobility of ileum and relaxes the valve
  • Flaps close when chyme exerts backwards pressure
50
Q

Large Intestine

A
  • Ileoceal Valve to anus > Diameter is 7cm and is about 1.5 m
  • Teniae Coli “ribbons of the colon”
    • three bands of longicudinal smooth muslce in muscularis
  • Hausta (Singular hasturm)
    • Pocketlike sacs cause by tone of teniae coli
  • Epilolic Appendages (membrane covered)
    • Fat-filled pouches of visceral peritoneum
51
Q

Subdivisions of the Large Intestine

A
  • Cecum) First Part of the larfe intestine
  • Appendix) masses of lymphoid tissue; contains MALT
    • storehouse of bacteria; recolonize the gut when needed
    • Suseptiable to blockage
  • Ascending Colon) Right side to level of kidney
    • Right Colic > (hepatic) flexure
  • Transsverse colon
    • Hepatic Flexure > Transverse Colon > Left colic (splenic) flexure
  • Descening colon
    • Splenic flexure > Descending colon
  • Sigmoid colon
    • in the pelvis
  • Rectum
    • Thre folds called rectal valves (stop feces being passed with gas)
  • Anal Canal
    • Last segemt of large intestine, opens to body exterior
    • Internal Anal Sphincter) smooth muscle
    • External Anal Sphincter) skeletal muscle
  • Colon is Retroperitonal
    • Except for transverse and sigmoid parts. (Anchored to mesenary sheets called mesocolons)
52
Q

Large Intestine: Microscopic Anatomy

A
  • Wall of Large Intsinte differs in several ways from the small intestine
    • Deeper Crypts with termendous globlet cells
    • Mucus eses the passage of feces
  • Thicker mucose of simple columnar epithelium
    • Anal Canal) stratified squamous to withstand abrasion
  • No absorbtion.
    • Folds are called anal colums
    • Anal sinuses) are recesses between anal columns
53
Q

Bacterial Flora

A
  • Consists of over a thousand types of bacteria
    • couple pounds of body weight
    • Most colanize colan via the anus
    • Some enter from small intestine
  • Metabolic Functions
    • recover energy from otherwise indgestible foods and syntethizize some vitamens
  • Fermentation
    • bacetria ferment indigestible carbohydrates. Can be absored by body cells afetwards
    • Produces gases (more when we eat indigesable carbs)
  • Vitamin Syntesis
    • B complex vitamins and some vitamin K are produced by gut bacteria
54
Q

Digestive Processes In the Large Intestine

A
  • Residue remains in large intesine 12-24 hours
  • No food breakdown except for gut bacteria
  • Vitamns, water, and electrolytes reclaimes
55
Q

Mobility of the Large intestine

A
  • Haustral Contactions
    • Slow segmenting movments that last about one min
    • Occur every 30 min or so
    • Contrat in respone to distension
  • Mass Movments
    • Presence of food in stomach activates gastroieal reflex in the small intesinte and gastrocholic rflex in colon
    • Activates three to four slow powerful peristaltic waves.
  • Fiber in diet makes colon movments easier
56
Q

Homeostatic Imbalance of the Colon

A
  • Diverticula (herniations of colon mucose dure to a low fiber diet.
    • Narrowed colon > stonger contractions > more pressure > hernia
    • Affects sigmoid colon
  • IBS) Reoccuring abdominal pain, stool changes, bloating, flatuence, nause and depression
57
Q

Defication

A
  • Mass Movments force feces toward Rectum
  • initited spinal Defication Reflex
    • Contraction of sigmoid colon and rectum
    • Relax internal anal sphincter
    • Assisted by vasalva’s manuever