Chapter 16--DO NOT STUDY Flashcards

Question 1

Q

Traumatic brain injury (TBI)

Answer

A

a wound to the brain that results from a blow to the head, is the most common form of brain damage in people under age 40. TBI commonly results from the head making impact with other objects

Question 2

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what do the brains of people with multiple concussions show?

Answer

A

extensive, diffuse loss of cerebral tissue.

Question 3

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Brain damage from TBI

Answer

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Trauma can disrupt the brain’s blood supply, induce bleeding (leading to increased intracranial pressure), cause swelling (leading to increased intracranial pressure), expose the brain to infection, and scar brain tissue (the scarred tissue becomes a focus for later epileptic seizures)

Question 4

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Concussion,

Answer

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the common term for mild traumatic brain injury (MTBI)

Question 5

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what is chronic traumatic encephalopathy characterized by?

Answer

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neurofibrillary tangles, plaques, and neuronal death. Cerebral atropy and expanded ventricles due to cell loss are typical in advanced cases.

Question 6

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what commonly accompanies TBI?

Answer

A

a loss of consciousness that may be brief (minutes) or prolonged (coma

Question 7

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what does the duration of unconsciousness during TBI tell you?

Answer

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serves as a measure of the severity of damage, because it correlates directly with mortality, intellectual impairment, and deficits in social skills.

Question 8

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two behavioral effects from TBI

Answer

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(1) impairment of the specific func- tions mediated by the cortex at the coup (the site of impact) or countercoup (opposite side) lesion (2) more generalized impairments from widespread trauma throughout the brain.

Question 9

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Movement of the hemispheres in relation to one another causes what?

Answer

A

tearing characterized by a loss of complex cognitive functions, including reductions in mental speed, concentration, and overall cognitive efficiency.

Question 10

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Traumatic brain injuries that damage the frontal and temporal lobes also tend to significantly affect what?

Answer

A

personality and social behavior

Question 11

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what is frustrating about TBI?

Answer

A

difficult to diagnose

Question 12

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N-acetylaspartate (NAA),

Answer

A

the second most abundant amino acid in the human brain

Question 13

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NAA &; TBI

Answer

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People with traumatic brain injuries show a chronic decrease in NAA that correlates with the severity of the injury

Question 14

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chronic traumatic encephalopathy (CTE)

Answer

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Progressive degenerative disease caused by multiple concussions and other closed-head injuries, characterized by neurofibrillary tangles, plaques, and cerebral atrophy and expanded ventricles due to cell loss.

Question 15

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magnetic resonance spectroscopy (MRS)

Answer

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Modification of MRI to identify changes in specific markers of neuronal function; promising for accurate diagnosis of traumatic brain injuries.

Question 16

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how long does recovery from head trauma last?

Answer

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may continue for 2 to 3 years and longer, but most cognitive recovery occurs in the first 6 to 9 months

Question 17

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recovery of memory symptoms in head trauma

Answer

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Recovery of memory functions appears to be slower than recovery of general intelligence, and the final level of memory performance is lower than for other cognitive functions.

Question 18

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People with brainstem damage,

Answer

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as inferred from oculomotor disturbance, have a poorer cognitive outcome, and a poorer outcome is probably true of people with initial dysphasias or hemiparesis as well.

Question 19

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what is significantly reduced after TBI?

Answer

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quality of life—in social inter- actions, perceived stress levels, and enjoyment of leisure

Question 20

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stroke

Answer

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an interruption of blood flow from either the blockage of a vessel or bleeding from a vessel.

Question 21

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ischemia

Answer

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Lack of blood to the brain as a result of stroke.

Question 22

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diaschisis

Answer

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Neural shock that follows brain damage in which areas connected to the site of damage show a temporary arrest of function.

Question 23

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neuroprotectant

Answer

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Drug used to try to block the cascade of poststroke neural events.

Question 24

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what happens in the first seconds to minutes after ischemia?

Answer

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changes begin in the ionic balance of the affected regions, including changes in pH and in the properties of the cell membrane.

Question 25

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stroke & glutamate

Answer

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Release of massive amounts of glutamate results in prolonged opening of calcium channels in cell membranes.

Question 26

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stroke & calcium channels

Answer

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Open calcium channels in turn allow toxic levels of calcium to enter the cell, not only producing direct toxic effects but also instigating various second-messenger pathways that can harm neurons. In the ensuing minutes to hours, mRNA is stimulated, altering the production of proteins in the neurons and possibly proving toxic to the cells.

Question 27

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brain swelling & TBI

Answer

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Brain tissues become inflamed and swollen, threatening the integrity of cells that may be far removed from the stroke site. As in TBI, an energy crisis ensues as mitochondria reduce their production of ATP to produce cerebral energy.

Question 28

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neuronal shock & TBI

Answer

A

A form of neural shock occurs. During this diaschisis, areas distant from the damage are functionally depressed. Thus, not only are localized neural tissue and its function lost but areas related to the damaged region also suffer a sudden withdrawal of excitation or inhibition.

Question 29

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stroke & metabolism

Answer

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Stroke may also be followed by changes in the metabolism of the injured hemi- sphere, its glucose utilization, or both, which may persist for days. Like diaschisis, these metabolic changes can have severe effects on the functioning of otherwise normal tissue. For example, after a cortical stroke, metabolic rate has been shown to decrease about 25 percent throughout the rest of the hemisphere.

Question 30

Q

tissue plasminogen activator (t-PA)

Answer

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clot-busting drug; must be administered within 3 to 5 hours to be effective; ideal treatment is to restore blood flow in blocked vessels before the cascade of nasty events begins.

Question 31

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constraint-induced therapy,

Answer

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confronts a problem in poststroke recovery related to learned nonuse. For example, stroke patients with motor deficits in a limb often compensate by overusing the intact limb, which in turn leads to increased loss of use in the impaired limb.

Question 32

Q

what is done in constraint-induced therapy?

Answer

A

the intact limb is held in a sling for several hours per day, forcing the patient to use the impaired limb

Question 33

Q

what can help augment speech therapy after a left-hemisphere stroke?

Answer

A

music and singing

Question 34

Q

epilepsy

Answer

A

a person suffers recurrent seizures that register on an electroencephalogram (EEG) associated with disturbances of consciousness; 1 person in 20 experiences at least one seizure in his or her lifetime

Question 35

Q

what three symptoms are found within the variety of epileptic episodes?

Answer

A

aura, loss of consciousness, seixures

Question 36

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aura

Answer

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or warning, of impending seizure may take the form of a sensation—an odor or a noise—or may simply be a “feeling” that the seizure is going to occur.

Question 37

Q

loss of consciousness

Answer

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ranges from complete collapse in some people to simply staring off into space in others. The period of lost consciousness is often accompanied by amnesia, including forgetting the seizure itself.

Question 38

Q

seizures

Answer

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commonly have a motor component, but as noted, the movement characteris- tics vary considerably. Some people shake; others exhibit automatic movements, such as rubbing the hands or chewing.

Question 39

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Jacksonian focal seizures

Answer

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for example, the at- tack begins with jerking movements in one part of the body—a finger, a toe, or the mouth—and then spreads to adjacent parts

Question 40

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Complex partial seizures

Answer

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originate most commonly in the tem- poral lobe and somewhat less frequently in the frontal lobe

Question 41

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three common manifestations of Complex partial seizures

Answer

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Subjective experiences, Automatisms, Postural changes,

Question 42

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subjective experiences in complex partial seizures

Answer

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for example, forced, repetitive thoughts, alterations in mood, feelings of déjà vu, or hallucinations—before the attack

Question 43

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automatisms in complex partial seizures

Answer

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repetitive, stereotyped movements such as lip smacking or chewing or activities such as undoing buttons during the attack

Question 44

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postural changes in complex partial seizures

Answer

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such as when the person assumes a catatonic (frozen) posture, during the attack

Question 45

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symptomatic seizure

Answer

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Identified with a specific cause, such as infection, trauma, tumor, vascular malformation, toxic chemicals, very high fever, or other neurological disorders.

Question 46

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idiopathic seizure

Answer

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Appears spontaneously and in the absence of other diseases of the central nervous system.

Question 47

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focal seizure

Answer

A

Seizure that begins locally (at a focus) and then spreads out to adjacent areas.

Question 48

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automatism

Answer

A

Unconscious, repetitive, stereo- typed movement characteristic of seizure.

Question 49

Q

catatonic posture

Answer

A

Rigid or frozen pose resulting from a psychomotor disturbance.

Question 50

Q

grand mal seizure

Answer

A

Seizure characterized by loss of consciousness and stereotyped motor activity.

Question 51

Q

postictal depression

Answer

A

Postseizure state of confusion and reduced affect.

Question 52

Q

petit mal seizure

Answer

A

Seizure of brief duration, characterized by loss of awareness with no motor activity except for blinking, turning the head, or rolling the eyes.

Question 53

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4 stages of grand mal seizures

Answer

A

tonic stage (body stiffens and breathing stops) 2. clonic stage (rhythmic shaking) 3. postseizure postictal depression 4. a period of coma after the seizure ends

Question 54

Q

how long to petit mal seizures last?

Answer

A

typically less than 10 seconds

Question 55

Q

The treatment of choice for epilepsy

Answer

A

anticonvulsant drugs, including diphenylhy- dantoin (DPH, Dilantin), phenobarbital, or one of about twenty other approved drugs; mainly sedative and anesthetic agents when given in low doses

Question 56

Q

A major site of action in epilepsy medications

Answer

A

the inhibitory GABAA receptor, which acts on a wide variety of neurons.

Question 57

Q

multiple sclerosis

Answer

A

the myelin that encases axons is damaged and the functions of the neurons disrupted. MS is characterized by the loss of myelin in both motor and sensory tracts and nerves. The myelin sheath and in some cases the axons are destroyed in both brain and spinal cord

Question 58

Q

autoimmune disease

Answer

A

Illness resulting from the loss of the immune system’s ability to discriminate between foreign pathogens in the body and the body itself.

Question 59

Q

dementia

Answer

A

Acquired and persistent syndrome of intellectual impairment characterized by memory and other cognitive deficits and impairment in social and occupational functioning.

Question 60

Q

prevalence of dementias

Answer

A

affect from 1 to 6 percent of the population older than age 65 and from 10 to 20 percent older than age 80.

Question 61

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Nondegenerative dementias,

Answer

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a heterogeneous group of disorders with diverse eti- ologies, including diseases of the vascular or endocrine systems, inflammation, nutri- tional deficiency, and toxic conditions

Question 62

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Degenerative dementias

Answer

A

presumably have a degree of genetic transmission; Parkinson’s disease and Alzeimer’s disease

Question 63

Q

what is implicated in Parkinson’s?

Answer

A

seems related to degeneration of the substantia nigra and to the loss of the neurotransmitter dopamine produced there and released in the striatum.

Question 64

Q

onset of Parkinson’s

Answer

A

The symptoms of Parkinson’s disease begin insidiously, often with a tremor in one hand and slight stiffness in the distal parts of the limbs. Movements may then become slower, the face becoming masklike with loss of eye blinking and poverty of emotional expression.

Answer 65

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are tremor, rigidity, loss of spontaneous movement (akinesia), and disturbances of posture.

Answer 66

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tremor at rest, muscular rigidity, involuntary movements

Answer 67

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Alternating movements of the limbs occur when they are at rest and stop during voluntary movements or sleep.

Answer 68

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Rigidity,or increased muscle tone simultaneously in both extensor and flexor muscles, is particularly evident when the limbs are moved passively at a joint. Movement is resisted, but with sufficient force, the muscles yield for a short distance and then resist movement again. Thus, complete passive flexion or exten- sion of a joint occurs in a series of steps, giving rise to the term cogwheel rigidity.

Answer 69

A

Small movements or changes in posture, sometimes referred to as akathesia or “cruel restlessness,” may be concurrent with general inactivity to relieve tremor and sometimes to relieve stiffness but often occur for no apparent reason. Other involuntary movements are distortions of posture, such as occur dur- ing oculogyric crisis (involuntary turns of the head and eyes to one side), which last for periods of minutes to hours.

Answer 70

A

disorders of posture, disorders of righting, disorders of locomotion, speech disturbance, akinesia

Answer 71

A

A disorder of fixation; Disorders of equilibrium

Answer 72

A

A person has difficulty in achieving a standing position from a supine position. Many advanced patients have difficulty even in rolling over.

Answer 73

A

Normal locomotion requires support of the body against gravity, stepping, balancing while the weight of the body is transferred from one leg to the other, and pushing forward. Parkinson patients have difficulty initiating stepping. When they do walk, they shuffle with short footsteps on a fairly wide base of sup- port because they have trouble maintaining equilibrium when shifting weight from one leg to the other. On beginning to walk, Parkinson patients often demonstrate festination: they take faster and faster steps and end up running forward.

Answer 74

A

One symptom most noticeable to relatives is the almost complete absence of prosody (rhythm and pitch) in the speaker’s voice.

Answer 75

A

Poverty or slowness of movement may also manifest itself in a blankness of facial expression, a lack of blinking or swinging the arms when walking, a lack of spontaneous speech, or an absence of normal fidgeting. Akinesia is also manifested in difficulty making repetitive movements, such as tapping, even in the absence of rigidity. People who sit motionless for hours show akinesia in its most striking manifestation.

Answer 76

A

presents as an inability or difficulty in main- taining a part of the body in its normal position in relation to other parts. A person’s head may droop forward or a standing person may gradually bend forward, ending up on the knees

Answer 77

A

create difficulties in standing or even sitting unsupported. In less severe cases, people may have difficulty standing on one leg, or if pushed lightly on the shoulders, they may fall passively without taking corrective steps or attempting to catch themselves.

Answer 78

A

impoverishment of feeling, libido, motive, and attention; people may sit for hours, apparently lacking the will to begin or con- tinue any activity.

Answer 79

A

loss of cells in the substantia nigra—may be due to disease, such as encephalitis or syphilis, to drugs such as MPTP, or to unknown causes. Idiopathic causes—those related to the individual—may include environmental pollutants, insecticides, and herbicides;

Answer 80

A

(1-methyl-4-phenylpyridinium), a modi- fied form of heroin that causes Parkinson’s disease.

Answer 81

A

physical therapy, psychological treatment, music and exercise therapy, drugs

Answer 82

A

To increase the activity in whatever dopamine synapses remain 2. Tosuppresstheactivityinstructuresthatshowheightenedactivityintheabsenceof adequate dopamine action

Answer 83

A

l-Dopa is converted into dopamine in the brain and enhances effective dopamine transmission; Naturally occurring anticholinergic drugs, block the cholinergic systems of the brain that seem to show heightened activity in the absence of adequate dopamine activity.

Answer 84

A

A newer course of treatment proposes to increase the number of dopamine cells either by transplanting stem cells that could then be induced to take a dopaminergic phenotype or by stimulating the production of endogenous stem cells and their migration to the basal ganglia

Answer 85

A

include the presence of the Apoe4 gene, below-average IQ, poor education, and TBI.

Answer 86

A

emergence of amyloid plaques (clumps of protein from dead neurons and astrocytes), chiefly in the limbic cortex and neocortex. Increased plaque concentration in the cortex has been cor- related with the magnitude of cognitive deterioration; neurofibrillary tangles (accu- mulations of microtubules from dead cells) found in both the neocortex and the limbic cortex, where the posterior half of the hippocampus is affected more severely than the anterior half

Answer 87

A

the cortex atrophies (shrinks) and can lose as much as one-third of its volume as the disease progresses

Answer 88

A

the primary sensory and motor areas, especially the visual cortex and the sensory–motor cortex, are relatively spared.

Answer 89

A

The entorhinal cortex is affected earliest and most severely. The entorhinal cortex is the major relay for information from the neocortex traveling to the hippocampus and related structures, then back to the neocortex. Entorhinal damage is associated with memory loss.

Answer 90

A

loss of dendritic arborization

Answer 91

A

Exelon, the trade name for rivastigmine, a cholinergic agonist that appears to provide temporary relief from disease progression.

Answer 92

A

Aging is associated with declines in perceptual functions, especially vision, hearing, and olfaction, and declining motor, cognitive, and executive (planning) functions as well.

Answer 93

A

aging is correlated with a decrease in white-matter volume probably related to myelin loss; reduction in neurogenesis in the hippocampus.

Answer 94

A

on tests of working memory as well as attentional and executive tasks.

Answer 95

A

a chronic cerebrovascular condition, marginal high blood pressure. Marginal elevations in blood pressure can lead to cerebral microbleeds, especially in white matter.

Answer 96

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Circular fibrous structure found in several neurodegenerative disorders; forms within the cytoplasm of neurons and is thought to result from abnormal neurofilament metabolism.

Answer 97

A

Disorder characterized predominantly by positive symptoms (e.g., behavioral excesses such as hallucinations and agitated movements) likely due to a dopaminergic dysfunction and associated with acute onset, good prognosis, and a favorable response to neuroleptics.

Answer 98

A

Disorder characterized by negative symptoms (behavioral deficits) and associated with chronic affliction, poor prognosis, poor response to neuroleptics, cognitive impairments, enlarged ventricles, and cortical atrophy, particularly in the frontal cortex.

Answer 99

A

70% in identical twins

Answer 100

A

Typically, schizophrenia is diagnosed in young adulthood, but a body of evidence suggests that its origins occur much earlier in development, even prenatally. Its expression in adulthood must therefore await the conclusion of a host of developmental processes that ultimately shape the adult human brain.

Answer 101

A

especially in the temporal and frontal lobes; 1. Suggesting cell loss in these areas, the schizophrenic brain generally has large ven- (B) tricles and thinner cortex in the medial temporal regions and frontal cortex. 2. Some aspects of the composition of neurons and fibers of the temporal lobes and the frontal lobes are changed. 3. Show abnormal dendritic fields in cells in the dorsal prefrontal regions; in the hippocampus and in the entorhinal cortex

Answer 102

A

in particular, abnormalities in dopamine and dopamine recep- tors and in GABA and GABA-binding sites. Recent evidence also suggests changes in glutamate receptors in schizophrenia,

Answer 103

A

Dopamine abnormalities were the first to be linked to schizophrenia. First, that most neuroleptic drugs act on the dopamine synapse was taken as evidence that schizophrenia is a disease of heightened activity in the ventral tegmental dopamine system. Second, drugs that enhance dopaminergic activity, such as amphetamine, can produce psychotic symptoms reminiscent of schizophrenia.

Answer 104

A

antidepressants act, at least in part, on signaling pathways, such as on cAMP, in the postsynaptic cell. Neurotrophic factors appear to affect the action of antidepressants and furthermore may underlie the neurobiology of depression. Investigators know, for example, that brain- derived neurotrophic factor (BDNF) is down-regulated by stress and up-regulated by antidepressant medication; Antidepressant medication may increase the release of BDNF through its actions on cAMP.

Answer 105

A

When we are stressed, the HPA axis is stimulated to secrete corticotropin-releasing hormone, which stimulates the pitu- itary to produce adrenocorticotropic hormone (ACTH). ACTH circulates through the blood and stimulates the adrenal medulla to produce cortisol. Normally, cortisol helps us deal with stress. If we cannot cope, or if stress is intense, excessive cortisol can wield a negative influence on the brain, damaging the feedback loops the brain uses to turn off the stress response.

Answer 106

A

the noradrenergic and serotoninergic activating systems modulate hormone secretion by the hypothalamic-pituitary-adrenal system—the HPA axis

Answer 107

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Excessive stress in early life may be especially detrimental; can perma- nently disrupt the reactivity of the HPA axis so that it is constantly overactive

Answer 108

A

Hypothalamic-pituitary-adrenal circuit that controls the production and release of hormones related to stress.

Answer 109

A

Problem-focused, action-oriented, structured, treatment for eliminating dysfunctional thoughts and maladaptive behaviors.

Answer 110

A

Imaging studies of people with anxiety disorders record increased baseline activity in the cingulate cortex and parahippocampal gyrus and an enhanced response to anxiety- provoking stimuli in the amygdala and prefrontal cortex.

Answer 111

A

Brain-function enhancement by pharmacological, physiological, or surgical manipulation.

Answer 112

A

The phenomenon in which an individual acquires a new skill after an injury

Answer 113

A