Chapter 11 - Muscular Physiology Flashcards
3 general functions of muscles
- Movement of the body as a whole or movement of its parts
- Heat production
- Posture
3 Characteristics of skeletal muscle cells
- Excitability (irritability)
- Contractility and produce body movement
- Extensibility
Characteristics of skeletal muscle cells: ability to be stimulated
Excitability (irritability)
Characteristics of skeletal muscle cells ability to contract, or shorten, and produce body movement
Contractility
Characteristics of skeletal muscle cells: ability to contract, or shorten, and produce body movement
Contractility
Muscle cells are called ___________ because of their threadlike ____________
fibers, shape
plasma membrane of muscle fibers
Sarcolemma:
Membrane of the ____________ ____________ continually pumps calcium ions from the sarcoplasm and stores the ions within its sacs for later release
Sarcoplasmic reticulum (SR)
network of tubules and sacs found within muscle fibers
T tubules
True or false
Muscle fibers contain many mitochondria and several nuclei
true
numerous fine fibers packed close together in sarcoplasm
Myofibrils
Segment of myofibril between two successive Z disks
Sarcomere
Each myofibril consists of many _____________
Sarcomeres
Contractile unit of muscle fibers
Sarcomere
Striated muscle has 2 stripes:
- light
2. dark
Light stripes called ____ bands
I
Dark stripes called ____ bands
A
light _____ zone runs across the midsection of each dark A band
H
dark _____ disk extends across the center of each light I band
Z
Transverse tubules extend across the sarcoplasm at right angles to the long axis of the muscle fiber
T tubules
Formed by inward extensions of the sarcolemma
T tubules
Membrane has ion pumps that continually transport calcium ions inward from the sarcoplasm
T tubules
Allow electrical impulses traveling along the sarcolemma to move deeper into the cell
T tubules
Triplet of tubules; a T tubule sandwiched between two sacs of SR
Triad
Allows an electrical impulse traveling along a T tubule to stimulate the membranes of adjacent sacs of the SR
Triad
Each myofibril contains thousands of thick and thin _______________
myofilaments
4 different kinds of protein molecules make up myofilaments
- Myosins
- Actin
- Tropomyosin
- Troponin
the myofilament protein molecule characterized as: Makes up almost all the thick filament
myosin
the myofilament protein molecule characterized as: the heads are chemically attracted to actin molecules
myosin
the myofilament protein molecule characterized as: the “heads” are known as cross bridges when attached to actin
myosin
the myofilament protein molecule characterized as: globular protein that forms two fibrous strands twisted around each other to form the bulk of the thin filament
Actin
the myofilament protein molecule characterized as: protein that blocks the active sites on actin molecules
Tropomyosin
the myofilament protein molecule characterized as: protein that holds tropomyosin molecules in place
Troponin
Thin filaments attach to both Z disks (Z lines) of a ____________ and extend partway toward the center
sarcomere
Thick ___________ filaments do not attach to the Z disks
myosin
3 mechanisms of muscle contraction
- excitation and contraction
- relaxation
- energy sources for muscle contraction
A skeletal muscle fiber remains at rest until mechanism of muscle contraction: stimulated by a motor neuron
excitation and contraction
this mechanism of muscle contraction involves motor neurons connecting to the sarcolemma at the motor endplate
excitation and contraction (neuromuscular junction)
this mechanism of muscle contraction involves a synapse where neurotransmitter molecules transmit signals
excitation and contraction (neuromuscular junction)
in excitation and contraction, this neurotransmitter is released into the synaptic cleft that diffuses across the gap, stimulates the receptors, and initiates an impulse in the sarcolemma
acetylcholine
in excitation and contraction, a nerve impulse travels over the _____________ and inward along the T tubules, which triggers the release of calcium ions (Ca++)
sarcolemma
in excitation and contraction, Ca++ binds to _____________, which causes tropomyosin to shift and expose active sites on actin
troponin
The 4 stages of the sliding filament model
- When active sites on actin are exposed, myosin heads bind to them
- Myosin heads bend and pull the thin filaments past them
- Each head releases, binds to the next active site, and pulls again
- The entire myofibril shortens
this phase of muscle contraction is characterized when the SR begins actively pumping it back into the sacs immediately after Ca++ is released
relaxation
in this phase of muscle contraction, Ca++ is removed from the troponin molecules, thereby shutting down the contraction
relaxation
A nerve impulse reaches the end of a motor neuron and triggers release of the neurotransmitter _______________
acetylcholine (ach)
Ach diffuses rapidly across the gap of the neuromuscular junction and binds to Ach receptors on the motor endplate of the muscle fiber is characteristic of muscle ___________ and ______________
contraction, excitation
in muscle contraction and excitation, Ca++ is released from the SR into the _______________, where it binds to troponin molecules in the thin _________________.
sarcoplasm, myofilaments
in muscle contraction and excitation, ___________ molecules in the thin myofilaments shift and thereby expose actin’s active sites.
Tropomyosin
in muscle contraction and excitation, energized ____________ cross bridges of the thick myofilaments bind to ___________ and use their energy to pull the thin myofilaments toward the center of each sarcomere. The cycle repeats itself many times per second, as long as ___________ _______________ is available.
myosin, actin, adenosine triphosphate
in muscle contraction and excitation, as the filaments slide past the thick ______________, the entire muscle fiber ________________
myofilaments, shortens
in muscle relaxation, once the impulse is over, the ____ begins actively pumping Ca++ back into its sacs
SR
In muscle relaxation, as Ca++ is stripped from troponin molecules in the thin myofilaments _____________ returns to its position and blocks actin’s active sites
tropomyosin
In muscle relaxation, Myosin cross bridges are prevented from binding to actin and thus can no longer sustain the _______________.
contraction
In muscle relaxation, because the thick and thin ______________ are no longer connected, the muscle fiber may return to its longer, _____________ length.
myofilaments, resting
In muscle relaxation, stimulation of _______________ receptors initiates an impulse that travels along the sarcolemma, through the T tubules, to the sacs of the ______________ ______________ (SR)
acetylcholine (ach), sarcoplasmic reticulum
Hydrolysis of _______________ ______________ yields the energy required for muscular contraction
adenosine triphosphate (ATP)
true or false
Muscle fibers can store large amounts of ATP
false
Muscle fibers must continually ____________ ATP since they can store only small amounts.
resynthesize
In muscle fiber only ___-___ seconds of max contraction
2-4
____________ ___________ in muscle can be broken down for energy—20 additional seconds of max muscle contratction
Creatine Phosphate
ATP binds to the ________ head and transfers its energy there to perform the work of pulling the thin ___________ during contraction
myosin, filament
ATP and CP are continually resynthesized—or re-charged –by ___________ _____________.
cellular respiration
Ultimately, energy for both ATP and CP synthesis comes from ________________ of food.
catabolism
Efficient nutrient catabolism by muscle fibers requires __________ and _____________
glucose, oxygen (O2)
Skeletal muscle contraction produces _________ ___________ that can be used to help maintain the set point body temperature
waste heat
At ___________, excess O2 in the sarcoplasm is bound to myoglobin
rest
this type of respiration occurs when adequate O2 is available from blood
Aerobic respiration
True or false
Aerobic respiration is faster than anaerobic respiration; thus supplies energy for the long term rather than the short term
false