Ch 5 Flashcards
Genus Features of Mycobacterium tuberculosis is ?
➢ Acid fast rods with waxy cell wall
➢ Obligate aerobe
Cell wall
▪ Complex, lipid-rich (mycolic acids) cell wall responsible for acid-
fastness and immune evasion.
▪ Cell wall proteins act as antigens, stimulating cellular immune
responses
mycobacteria highly resistant to ?
desiccation and many
chemicals
M. canetti is
a very rare and genetically primitive
member of the complex.
M. microti is ?
a rarely encountered pathogen of voles and other
small mammals, but which is attenuated in humans
M. pinnipedi is ?
an uncommon pathogen of seals and a very
rare cause of tuberculosis in those occupationally exposed to
seals
M. caprae is ?
isolated from goats and the cause of a few cases
of tuberculosis in veterinary surgeons
M. bovis is ?
the principal cause of tuberculosis in cattle and
many other mammals including humans
Mycobacterium tuberculosis Features is ?
Auramine-rhodamine staining bacilli (fluorescent
apple green Acid fast, Aerobic, slow growing, Lowenstein-Jensen medium, Produces niacin, Produces a heat-sensitive catalase
Sulfatides is ?
inhibit phagosome-lysosome
fusion, allowing intracellular survival
pulmonary TB involves?
caseation, calcification and
cavity formation
higher risk for rapid TB disease is ?
HIV-infected individuals
انتشار مرض السل والعدوى يكون في أي نوع من السل ؟
Post-primary
غالباً ال Post-primary يكون في أي مكان في ال lung ؟
Apical region
Positive skin test indicates only
exposure but not
necessarily active disease
يتم زراعة الTB على وسط ؟
Löwenstein-Jensen or Middlebrook media
اول شهرين من مرض TB يتم إعطاء ؟
rifampin + isoniazid + pyrazinamide + ethambutol
ما هي الأدوية التي تم اعطائها في حالمان Resestans ل rifampin and isoniazid ؟
aminoglycosides, fluoroquinolones, thioamide, cycloserine, bedaquiline
ما هو ال vaccine المستخدم ل TB ؟
Bacille Calmette-Guérin (BCG)
Distinguishing Features for Mycobacterium leprae is ?
Acid fast rods , Obligate intracellular parasite
Treatment of Paucibacillary form is ?
Rifampicin + Dapsone
