Ch 14

Question 1

Bordetella character is ?

Answer 1

Small (0.2-0.5 x 1 μm), aerobic, Gram-negative coccobacillus
-invasive, strictly human pathogen

Question 2

4cause human disease is ?

Answer 2

Bordetella pertussis
Bordetella bronchiseptica
Bordetella parapertussis
Bordetella holmesii

Question 3

Attachment mediated to B. pertussis is ?

Answer 3

▪ Pertactin
▪ Filamentous hemagglutinin
▪ Fimbriae

Question 4

Dermonecrotic toxin ?

Answer 4

causes ischemia

Question 5

Tracheal cytotoxin

Answer 5

inhibits cilia, causing cough

Question 6

Pertussis toxin increases

Answer 6

cAMP, leading to excess mucus production

Question 7

Pertussis toxin is an ?

Answer 7

oligopeptide AB-type
exotoxin that is the major cause of pertussis
(abnormal cough)

Question 8

سو بعمل ال Pertussis toxin ؟

Answer 8

abnormal cough
T cell lymphocytosis and has adjuvant
properties
Inhibits many leukocyte functions, including
chemotaxis, phagocytosis and respiratory burst
and impairs NK cell killing
Hypoglycemia, increased IgE synthesis, and
increased histamine and endotoxin sensitivity

Question 9

LPS of other gram-negative bacteria, these ?

Answer 9

endotoxins

Question 10

LPS cause ?

Answer 10

number of patho-physiolocigal effects

Question 11

Bordetella pertussis Clinical Stages is ?

Answer 11

Catarrhal Stage
Convalescent Stage
Paroxysmal Stage

Question 12

Bordetella pertussis Diagnosis is ?

Answer 12

➢ Culture: Requires special media (charcoal, starch, blood, or albumin);
difficult to recover.
➢ Nucleic Acid Amplification Tests (NAATs): Highly sensitive, diagnostic
test of choice.
➢ Serology: ELISA detects antibodies against pertussis toxin and adhesins

Question 13

Bordetella pertussis Treatment?

Answer 13

Macrolides (azithromycin, clarithromycin, erythromycin) preferred.
Alternative: Trimethoprim-sulfamethoxazole

Question 14

Vaccination of Bordetella pertussis is ?

Answer 14

Pediatric (DTaP)
Adult (Tdap)

Question 16

Legionnaires’ Disease symptoms is ?

Answer 16

▪ Severe atypical pneumonia with fever, chills, dry cough.
▪ Multiorgan involvement (GI, CNS, liver, kidneys

Question 17

Culture (Gold Standard) is ?

Answer 17

Requires Buffered Charcoal Yeast Extract (BCYE)
agar

Question 18

Urinary Antigen Test is ?

Answer 18

Rapid, detects L. pneumophila serogroup 1 but not
other serogroups

Question 19

Nucleic Acid Amplification Tests (NAATs) is ?

Answer 19

Highly sensitive for respiratory
specimens

Question 20

ما هي طرق التعقيم الماء ؟

Answer 20

Hyperchlorination, copper-silver ionization, and UV light disinfection of water
sources

Question 21

Legionnaires’ Disease Treatment?

Answer 21

❖ Macrolides (azithromycin, clarithromycin) or fluoroquinolones
(levofloxacin, ciprofloxacin).
Tetracyclines and rifampin