Ch 17 Flashcards
من الذي يسبب ال parodontitis ?
T. denticola
من الذي يسبب ال yaws؟
T. pertenue
من الذي يسبب ال bejel؟
T. endemicum
General Overview of Spirochaetales is ?
➢ Gram-negative spirochetes
• Spirochete from Greek for “coiled hair”
➢Extremely thin and can be very long
➢ Tightly coiled helical cells with tapered ends
➢ Motile by periplasmic flagella
Treponema pallidu seen on Gram stain T/F ?
F
Axial filaments =
endoflagella = periplasmic flagella
Treponema pallidum Reservoir is ?
human genital tract
Treponema pallidum Transmission is ?
transmitted sexually, across the placenta or Blood
transfusion (rare)
Tissue destruction and lesions are primarily a consequence of ?
patient’s immune response
Syphilis is a disease of ?
blood vessels and of the perivascular
areas
Outer membrane proteins promote
adherence
Hyaluronidase may facilitate
perivascular infiltration
شو هو ال fibronectin ؟
طبقة بتغطي البكتيريا حالها فيها وتعتبر هذه الطبقة Antiphagocytic
chancre (usually painless) is ?
hallmark syphilitic lesion
Primary lesion heals spontaneously by
fibrotic walling-
off within two months, leading to false sense of relief
Late neurosyphilis symptoms is ?
❖ Central nervous system and spinal cord involvement
❖ Dementia, seizures, wasting, etc
Cardiovascular involvement appears 10-40 years after initial infection with
resulting
myocardial insufficiency and death
Early Neurosyphilis is ?
- Asymptomatic
- Symptomatic (Meningitis, Cran
Neuritis, Ocular involvement,
Meningiovascular Disea -)
In Congenital Syphilis the Late mental or physical problems
▪ Rhinitis, rash
▪ Bone/teeth deformities, deafness, blindness
T. pallidum Diagnostic Test is ?
Microscopy (Darkfield
Direct fluorescent antibody staining)
Serology
Serology is?
Nontreponemal tests
Treponemal tests
Nontreponemal tests is ?
Venereal Disease Research Laborratory (VDRL)
Rapid Plasma Reagin
Treponemal tests is
Fluorescent treponemal antibody absorption (FTA-ABS)
Microhemagglutination test for Treponema pallidum
(MHA-TP)
Pinta Transmission by ?
(skin contact)
