ch 48

Question 1

main NT for PNS

Answer 1

acetylcholine

Question 2

main receptor for PNS

Answer 2

cholinergic receptors

Question 3

cholinergic drugs act on the PNS –> SLUDD

Answer 3

salivation, lacrimation, urination, digestion, defecation

Question 4

S/S: patient’s body produces antibodies attacking acetylcholine receptors; eye, face, swallowing most commonly affected

Answer 4

myasthenia gravis

Question 5

what drug treats myasthenia gravis?

Answer 5

neostigmine

Question 6

• decrease inactivation acetylcholine resulting in increased skeletal muscle tone/strength
• AE: salivation, drooling, more peristalsis (diarrhea)
• can cause bronchioleconstriction, slowed HR

Answer 6

neostigmine (Bloxiverz)

Question 7

most common form of dementia; acetylcholine levels decreased

Answer 7

alzheimer’s disease

Question 8

what drug is for alzheimer’s disease?

Answer 8

donepezil

Question 9

• elevates acetylcholine and improves memory
• AE: frequent urination, CNS related
• give at bedtime

Answer 9

donepezil (Aricept)

Question 10

T/F: donepezil will help memory but doesn’t cure disease, only slowing the progression by increasing acetylcholine levels

Answer 10

T

Question 11

sensation of bladder fullness/incomplete bladder emptying, typically due to:
- neurologic bladder
- diabetes
- prostate enlargement
- general anesthesia

Answer 11

urinary retention

Question 12

what drug treats urinary retention?

Answer 12

bethanechol

Question 13

• increases contraction of detrusor muscle around bladder to promote bladder emptying
• AE: increased salivation, n/v, decreased HR/orthostatic hypotension
• administer on empty stomach

Answer 13

bethanechol (Urecholine)

Question 14

overstimulation of the PNS due to drugs is called

Answer 14

cholinergic crisis

Question 15

when administering cholinergic drugs, what should you always have available?

Answer 15

atropine