Ch 10 Bacterial DNA repair Flashcards
What is mutation?
A heritable change in the DNA
What is point mutation?
Change in a single base pair
What is transition?
Purine>purine
Pyrimidine>pyrimidine
What is transversion?
Purine>pyrimidine
Pyrimidine>purine
What is insertion?
Adding one or more bases
What is deletion?
Subtracting one or more bases
What is inversion?
DNA is flipped in orientation
What is reversion?
DNA mutates back to original sequence
What is a silent mutation?
Does not change the amino acid sequence
What is missense mutation?
Changes the amino acid sequence to another
What is nonsense mutation?
Changes the amino acid sequence to a stop codon
What is frame-shift mutation?
Changes the open reading frame of the gene
What are some mutagens?
Chemical agents, Electromagnetic radiation
Electromagnetic radiation: What do x-rays and gamma rays do?
Break DNA
Electromagnetic radiation: What do ultraviolet rays do?
Form pyrimidine dimers
What is the mutation rate?
Number of mutations formed per cell division
Mutation frequency?
Ratio of mutants per total cells in the population
What does the Ames test do?
Identifies mutagens
What are error-proof pathways?
They prevent mutations
What are error-prone pathways?
Risk introducing mutations when the cell has so much damage it has to mutate or die to survive