Cellular Injury, Adaptation, & Death Flashcards
Define: Hypertrophy
Increase in cell size
Define: Hyperplasia
Increase in cell number
Define: Atrophy
Decrease in cell size
Define: Metaplasia
Change in one type of cell to another
Define: Dysplasia
Change in cell organization
2 Components to Oxygen Depravation
1) Blood Flow
2) O2 Carriage
4 Types of Inflammation
1) Acute
2) Chronic
3) Antigen-driven
4) Nonantigen driven
8 Type of Disease Pathogenesis
1) Inflammation
2) Repair
3) Adaptive Growth
4) Change in cytoplasmic organelles
5) Necrosis
6) Apoptosis
7) Neoplasia
8) Maldevelopment
3 Major Types of Change in cytoplasmic organelles
1) Hydropic Change
2) Fatty Change
3) Lysosomal Storage
Most vulnerabe intracellular targets (5)
1) Plasma Membrane
2) Aerobic Respiration
3) Protein Synthesis
4) Cytoskeleton
5) Genetic Machinery
What types of cell injuries are usually reversible?
Acute, sublethal
Characteristic Morphologic changes found in Reversible Cell Injuries (6)
1) Hydropic swelling
2) ER swelling
3) Mitochondrial swelling
4) Membrane surface blebbing
5) Ribosomal detachment
6) Nuclear disaggregation
What determines the cell’s reaction to a stressor?
Frequency and Severity
What usually accompanies Hypertrophy?
Hyperplasia
Also linked to increase in cell function
What is the most common form of metaplasia?
Replacement of Glanduar Epithelium with Squamous Cells due to persistent injury
Fully Reversible
