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Anatomy > Antimicrobials > Flashcards

Antimicrobials Flashcards

1
Q

B-Lactams

A
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2
Q

Glycopeptides

A
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3
Q

Bacitracin

A
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4
Q

Cycloserine

A
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5
Q

Phosphonomycin

A

Process Targeted: Cell wall synthesis

Mechanism of Action: Inhibits NAM synthesis

Drug Inactivation: None

Altered Drug target: Rare

Altered Drug uptake: rare

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6
Q

Isoniazid

A
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7
Q

Ethambutol

A
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8
Q

Lipopeptides

A

Process targetedL Cell membrane integrity

Mechanism: Destabilizes Gram-positive cell membranes

Drug Inactivation: none

Altered Drug target: None

Altered Drug uptake: none

Other resistance: unknown

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9
Q

Aminoglycosides

A

Process Targeted: Translation

Mechanism: Binds 30S ribosomal subunit near A site

Drug Inactivation: APH, AAC, ANT

Altered Drug target: Rare

Altered drug uptake: Altered membrane potential

Other Resistance: None

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10
Q

Tetracyclines

A
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11
Q

Macrolides

A
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12
Q

Lincosamides

A
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13
Q

Streptogrammins

A

Process targeted: Translation

Mechanism: B-subunit binds 50S ribosome subunit blocking exiting peptide

Drug Inactivation: VGB

Altered Drug target: rRNA methylation

Altered drug uptake: Gram-positive efflux

Other resistance: none

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14
Q

Oxazolidinones

A
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15
Q

Fusidic Acid

A
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16
Q

Mupirocin

A
17
Q

Quinolones

A
18
Q

Rifamycins

A
19
Q

Sulfonamides

A
20
Q

Trimethoprim

A
21
Q

Diarylquinolines

A
22
Q

Nitrofurantoin

A

Process: Prodrug

Mechanism: Activated by nitroreductases to relase reactive nitrogen intermediates (RNI)

Drug inactivation: None

23
Q

Metronidazole

A

Process: prodrug

Mechanism: Activated by nitroreducates to release RNIs

Drug inactivation: none

Altered drug target: Loss of nitroreductase

Altered drug uptake: none

24
Q

Pyranzenamide

A

Process: prodrug

Mechanism: unknown

Drug inactivation: none

Altered Drug target:altered PncA

Altered drug uptake: none

Anatomy (18 decks)

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