CELL MEDIATED RESPONSES Flashcards

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1
Q

what are the two types of WBCs

A

phagocytes (neutrophils and macrophages)
lymphocytes (T and B lymphocytes and memory cells)

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2
Q

where do t lymphocytes mature

A

thymus gland

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3
Q

what are the subgroups of T cells

A

helper t
cytotoxic t

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4
Q

what do t lymphocytes recognise

A

antigens presented by macrophages

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5
Q

describe the cell mediated response

A
  1. Phagocytosis & phagocyte presents
    antigens (from pathogen) on membrane.
  2. Helper T cell receptor binds to antigens &
    is activated (release cytokines).
  3. Activated helper T cell divides quickly
    (mitosis- clonal expansion) and forms
    clones of genetically identical cells.
  4. Cloned cells respond to the pathogen in
    different ways-
    Stimulate more phagocytes 🡪 more
    phagocytosis
    Develop into memory cells 🡪 quicker
    response for secondary infections
    Stimulate B cells to multiply & release
    antibodies
    activate cytotoxic T cells
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6
Q

what do cytotoxic t cells do

A

bind to infected cells
perforin makes holes in infected cells membrane and enzyme enters
infected cell is destroyed

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