CD 19 Flashcards
Differentiate Topical vs Transdermal drug delivery?
Topical: localized treatment for a dermatological condition. i.e. Ointment
Transdermal: Product that use on the skin surface as a portal for systemic delivery of bioactive. i.e. patches for angina pain
Quiz: Absorption of a drug from a topically applied formulation is a complex process. The factor that determines whether a drug applied to the skin is absorbed is/are
A. The drug
B. The user
C. The formulation
D. All of the above (right Answer)
The primary barrier to drug permeation through the skin is?
The stratum corneum (right answer)
The viable epidermis
The dermis
None of above
What are the three main layers in skin structure?
Epidermis (it has 2 layers they are stratum corneum (dead cells) & viable(live) epidermis)
Dermis
Hypodermis (SC)
Epidermis has 2 layers they are?
Stratum corneum (dead cells) & viable(live) epidermis)
Drug transport through the skin can occur via a number of pathways?
A Intercellular (cell block er faky faky jay) B Intracellular (cell block er middle diya drug jay) C Follicular (hair follicle er gora diay drug jay)
What is the difference between Normal and Atopic skin?
Healthy skin: Evaporation of Transdermal water stay intact, and keratinocytes barrier stay packed as a result the oily barrier on our skin keep the skin hydrated and healthy skin.
Atopic skin: Evaporation of Transdermal water as result dry skin and chemical or infection or allergens can access through keratinocytes loosen barrier as a result cause infection or inflammation
What is the first main reason for atopic skin condition?
Loss of hydration
What are the treatment options for atopic conditions?
Topical products topical corticosteroids Oils Lotions Creams Ointments Pain reliever
What are moisturisers?
Occlusive (form a barrier on stratum corneum top layer)
They are humectants (reduce loss of water),
Emollients (soften skin),
What base Soap substitutes typically contain?
Base is called absorption base (contain w/o) called emulsifying agent.
Why emulsifying agent are used as a soap substitute?
Because they can hold or absorb large amounts of water (more than 50% of their volume) in the skin.
Steroid hormones are produced by which glands? and what is their location in our body?
by Adrenal glands, in the kidney.
Corticosteroids have anti-inflammatory, immunosuppressive and anti-proliferative action. Many of these actions are mediated by binding to the?
Glucocorticoid receptors (GRs)
Our body usually naturally produces steroid hormone by adrenal gland, one of them is (Cortisol other name hydrocortisone) is produced indigenously which means they made by our body.
What does cortisol/cortico-steroids/ hydrocortisone do in our body?
Anti-proliferative (lots of proliferation of cells)
Anti-inflammatory (pain remover)
So, when we use corticosteroids topically in our infected skin, they reduce abnormal proliferation of cells and stop inflammation.