Case 10 - Mental Health Flashcards

1
Q

Role of astrocytes in the brain

A

star-shaped cells that provide the scaffolding to the brain

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2
Q

Role of pericytes in the brain

A

induce the ‘tightness’ of the junctions maintaining the blood brain barrier

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3
Q

Causes of pathology in the blood brain barrier

A

meningitis
stroke
traumatic brain injury
haemorrhage

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4
Q

What is the monoamine theory of depression

A

too little serotonin

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5
Q

Role of the following neurotransmitters:

  • dopamine
  • noradrenaline
  • serotonin
  • acetylcholine
  • gamma amino-butyric acid
  • glutamate
  • glycine
A
dopamine = pleasure
noradrenaline = fight/flight
serotonin = mood
acetylcholine = muscle
gamma amino-butyric acid = major inhibitory
glutamate = major excitory
glycine = spinal cord inhibitory
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6
Q

Explain neurotransmitter termination

A

Diffusion out at synaptic cleft
Reuptake to synaptic membrane
degradation by enzymes

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7
Q

Mechanism of action of reuptake inhibitors

A

Neurotransmitter spends more time in the synaptic cleft by inhibiting the enzyme that breaks them down

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8
Q

Side of effects of eating foods containing tyramine on MAOs

A

Cannot be broken down, side effects include flushing, headaches and hypertension

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9
Q

What is serotonin syndrome

A

Too much serotonin causes anxiety, agitation, disorientation, and D&V

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10
Q

What is the purpose of sleep

A
restoration
hormone production
waste clearance
memory
mental health + behaviour
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11
Q

What is the circadian pacemaker

A

The suprachiasmatic nucleus

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12
Q

Sleep related neurotransmitters

A

Orexin
Melatonin
GABA
Adenosine

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13
Q

Stages of sleep

A
Wakefulness
N1
N2
N3
REM
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14
Q

Approximately how long does a sleep cycle take

A

90 minutes

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15
Q

Role of melatonin in regulating sleep

A

Builds throughout the day to make you feel sleepy

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16
Q

Role of adenosine in regulating sleep

A

Increases sleep pressure

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17
Q

Role of GABA in regulating sleep

A

Increases sleep pressure

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18
Q

Role of caffeine in regulating sleep

A

Blocks adenosine receptors

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19
Q

What are zeitgebers

A

Environmental stimuli that regulate the circadian rhythm

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20
Q

Examples of good sleep hygiene

A
Going to bed and waking at the same time
Relaxing routine
No big meals before bed
Exercise in the day not at bed time
Bed is for sleep only
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21
Q

What is insomnia and how is it treated

A

Decreased sleep quality/quantity for 3x per week over 3 months causing deficits

Treatment = sleep hygiene, medication, CBT

22
Q

What is obstructive sleep apnoea and how is it treated

A

Upper airway either completely or partially occluded while sleeping, may cut off air supply several times in a night

Treatment = CPAP

23
Q

Examples of hypersomnia conditions

A

Narcolepsy

Kleine-Levin Syndrome

24
Q

What is REM sleep behaviour disorder

A

People act out their dreams as they are not paralysed properly

25
What's the difference between nightmares and night terrors
Nightmares occur in the REM stage and can be remembered, night terrors do not and will not be remembered
26
Examples of NREM sleep disorders
Sleep walking Sleep eating/drinking Sleep talking Night terrors
27
What is the onset and endpoint of adolescence
``` Onset = puberty Endpoint = socially gaining independence ```
28
What is adrenarche
activation of hypothalamic-pituitary-adrenal axis, secondary sexual characteristics begin to develop
29
What is gonadarche
activation of the hypothalamic-pituitary-gonadal axis
30
how is the growth axis activated
Growth hormone secreted causing growth spurt
31
What is the impact of prolonged hypothalamic-pituitary-adrenal axis activation on growth
prolonged hypothalamic-pituitary-adrenal axis activation decreases growth hormone secretion. Children who experience ACEs are more likely to have prolonged HPA axis activation and so may be physically different to their peers
32
White matter changes in the adolescent brain
increase in white matter particularly in males
33
Grey matter changes in the adolescent brain
Region-specific, non-linear pattern of development Pre-pubertal increase followed by post-pubertal decrease due to synaptic pruning Motor and sensory systems mature before primary function systems
34
What does synaptic overpruning increase the risk of
Schizophrenia
35
Psychological symptoms of depression
* continuous low mood or sadness * feeling hopeless and helpless * having low self-esteem * feeling tearful * feeling guilt-ridden * feeling irritable and intolerant of others * having no motivation or interest in things * finding it difficult to make decisions * not getting any enjoyment out of life * feeling anxious or worried * having suicidal thoughts or thoughts of harming yourself
36
Physical symptoms of depression
* moving or speaking more slowly than usual * changes in appetite or weight (usually decreased, but sometimes increased) * constipation * unexplained aches and pains * lack of energy * low sex drive (loss of libido) * changes to your menstrual cycle * disturbed sleep – for example, finding it difficult to fall asleep at night or waking up very early in the morning
37
Social symptoms of depression
* avoiding contact with friends and taking part in fewer social activities * neglecting your hobbies and interests * having difficulties in your home, work or family life
38
Examples of SSRIs
citalopram fluoxetine sertraline
39
Examples of SNRIs
duloxetine
40
Triggers/causes of mental illness
* childhood abuse, trauma, or neglect * social isolation or loneliness * experiencing discrimination and stigma * social disadvantage, poverty or debt * bereavement (losing someone close to you) * severe or long-term stress * having a long-term physical health condition * unemployment or losing your job * homelessness or poor housing * being a long-term carer for someone * drug and alcohol misuse * domestic violence, bullying or other abuse as an adult * significant trauma as an adult, such as military combat, being involved in a serious incident in which you feared for your life, or being the victim of a violent crime * physical causes – for example, a head injury or a neurological condition such as epilepsy can have an impact on your behaviour and mood. (It's important to rule out potential physical causes before seeking further treatment for a mental health problem).
41
Differential diagnoses for mental health disorders
``` lead poisoning malingering hyperthyroidism mental retardation understimulation for intelligent children seizures chronic illness drug side effects ```
42
Stages of a mental state examination
``` Appearance and behaviour Speech Mood Thoughts Perception Cognition Insight ```
43
Types of auditory hallucination
2nd person - 'you are', 'you should' 3rd person - 'they are', 'they should' Thought echo - thoughts repeated back to them
44
What is a delusion
A fixed, false belief that cannot be changed by logic and are not consistent with culture or education
45
What is a hallucination
A false sensory perception without an external stimulus
46
What is an illusion
A misinterpretation of an existing stimulus
47
Examples of antipsychotics and side effects
Seroquel, Zyprexa Sedation, weight gain, involuntary movement, diabetes
48
Examples of antidepressants and side effects
Fluoxetine Citalopram Suicidal behaviours, weight loss, abnormal bleeding
49
Examples of mood stabilisers and side effects
Lithium Weight gain, nausea, diarrhoea, tremors
50
Examples of anti-ADHD medications and side effects
Adderall, Ritalin Growth delays, tics, insomnia, decreased appetite
51
Examples of anti-anxiety medications and side effects
Hydroxyzine Sedation, dizziness, dry mouth
52
Reasons to be sectioned
* you need to be assessed or treated for your mental health problem * your health would be at risk of getting worse if you did not get treatment * your safety or someone else's safety would be at risk if you did not get treatment * your doctor thinks you need to be assessed or treated in hospital, for example if you need to be monitored very regularly because you have to take new or very powerful medication. Otherwise, you may be asked to attend a hospital out-patient clinic.