Case 10 - Mental Health Flashcards
Role of astrocytes in the brain
star-shaped cells that provide the scaffolding to the brain
Role of pericytes in the brain
induce the ‘tightness’ of the junctions maintaining the blood brain barrier
Causes of pathology in the blood brain barrier
meningitis
stroke
traumatic brain injury
haemorrhage
What is the monoamine theory of depression
too little serotonin
Role of the following neurotransmitters:
- dopamine
- noradrenaline
- serotonin
- acetylcholine
- gamma amino-butyric acid
- glutamate
- glycine
dopamine = pleasure noradrenaline = fight/flight serotonin = mood acetylcholine = muscle gamma amino-butyric acid = major inhibitory glutamate = major excitory glycine = spinal cord inhibitory
Explain neurotransmitter termination
Diffusion out at synaptic cleft
Reuptake to synaptic membrane
degradation by enzymes
Mechanism of action of reuptake inhibitors
Neurotransmitter spends more time in the synaptic cleft by inhibiting the enzyme that breaks them down
Side of effects of eating foods containing tyramine on MAOs
Cannot be broken down, side effects include flushing, headaches and hypertension
What is serotonin syndrome
Too much serotonin causes anxiety, agitation, disorientation, and D&V
What is the purpose of sleep
restoration hormone production waste clearance memory mental health + behaviour
What is the circadian pacemaker
The suprachiasmatic nucleus
Sleep related neurotransmitters
Orexin
Melatonin
GABA
Adenosine
Stages of sleep
Wakefulness N1 N2 N3 REM
Approximately how long does a sleep cycle take
90 minutes
Role of melatonin in regulating sleep
Builds throughout the day to make you feel sleepy
Role of adenosine in regulating sleep
Increases sleep pressure
Role of GABA in regulating sleep
Increases sleep pressure
Role of caffeine in regulating sleep
Blocks adenosine receptors
What are zeitgebers
Environmental stimuli that regulate the circadian rhythm
Examples of good sleep hygiene
Going to bed and waking at the same time Relaxing routine No big meals before bed Exercise in the day not at bed time Bed is for sleep only
What is insomnia and how is it treated
Decreased sleep quality/quantity for 3x per week over 3 months causing deficits
Treatment = sleep hygiene, medication, CBT
What is obstructive sleep apnoea and how is it treated
Upper airway either completely or partially occluded while sleeping, may cut off air supply several times in a night
Treatment = CPAP
Examples of hypersomnia conditions
Narcolepsy
Kleine-Levin Syndrome
What is REM sleep behaviour disorder
People act out their dreams as they are not paralysed properly