Care of Patients with Musculoskeletal Problems II Flashcards
Loss of bone related to a vitamin D deficiency
Interventions:
Child form: rickets
Osteomalacia
Bones soften secondary to inadequate amounts of calcium and phosphorus in the bone matrix - not calcify properly without D
Loss of bone related to a vitamin D deficiency - Osteomalacia
Increase vitamin D intake through diet
Daily sun exposure
Vitamin D supplements
Interventions: - Osteomalacia
Milk, eggs, swordfish, chicken, liver, enriched cereals and bread products
Read labels that things high in D
Increase vitamin D intake through diet
5 minutes each day
UV radiation to activate D
Daily sun exposure
Ergocalciferol
Vitamin D supplements
Also called osteitis deformans
Second most common bone disease after osteoporosis
Pathophysiology
May occur in one bone or multiple sites - bone and joint pain; reforming not in proper way
Two types
Clinical manifestations
Increased risk for bone cancer
Diagnostic assessment
Interventions
Aspirin or NSAIDS for mild to moderate pain
Heat and gentle massage - help with pain
Exercise - good idea; weight bearing helps rebuild bone
Diet rich in calcium and Vitamin D - risk for hypocalcemia with bisphosphonates
Paget’s disease
Chronic metabolic disorder
Bone is excessively broken down and then reformed - increased osteoblasts and clasts
Bone is structurally disorganized
Bones are weak and at increased risk for fractures - not as strong
Risk for bowing
Pathophysiology - Paget’s disease
Familial and sporadic
Two types - Paget’s disease
Asymptomatic OR
Bone and joint pain
Pathological fractures
Bowing of long bones
Enlarged, thick skull
Clinical manifestations - Paget’s disease
Increase in serum alkaline phosphatase (ALP)
Increase in urinary hydroxyproline levels
Elevated uric acid
X-rays - enlarged bones; indicate make have paget’s
Bone scan - definitive; inject radioactive dye
Diagnostic assessment - Paget’s disease
Caused by overactive osteoblasts
Increase in serum alkaline phosphatase (ALP)
Indicates the degree of disease severity
Reflects bone collagen turnover/breaking down
Increase in urinary hydroxyproline levels
Oral bisphosphonates when ALP levels are at least twice the normal level - prevent breakdown bones
Monoclonal antibody
Calcitonin
Interventions - Paget’s disease
Ex. aldreonate (Fosamax); risedronate (Actonel)
Oral bisphosphonates when ALP levels are at least twice the normal level - prevent breakdown bones
Ex. denosumab (Prolia)
Binds to a protein that is essential for the formation, function, and survival of osteoclasts
Inhibits osteoclasts life
Monoclonal antibody
Hormone that reduces bone resorption and relieves pain
Given SQ
Used in patients that do not tolerate bisphosphonates
Prevent breaking down bone and resorption
Calcitonin