Assessment of the Hematologic System Flashcards
Responsible for blood formation
First produces blood stem cells
Red blood cells (RBCs, erythrocytes)
White blood cells (WBCs, leukocytes)
Platelets
Also has role in immune responses
Located in flat bones (sternum, skull, pelvic and shoulder girdles) and ends of long bones
Bone marrow
Stem cells (immature)are capable of becoming any type of blood cell, depending on the body’s needs
First produces blood stem cells
Composed of plasma and cells
Plasma is an extracellular fluid with plasma proteins (3 main)
Blood cells
Blood components
Albumin: maintain osmotic pressure of blood - prevents plasma from leaking into tissues
Globulins: transport of antibodies - Ig
Fibrinogen: important in clotting
Plasma is an extracellular fluid with plasma proteins (3 main)
Largest proportion of blood cells
Produce hemoglobin which carries oxygen and carbon dioxide
Iron is important component of hemoglobin - allows carry O2
RBCs - Blood cells
Role in inflammation and infection protection
WBCs - Blood cells
Smallest blood cell
Clotting and bleeding
Stick to injured vessel walls and aggregate to assist clotting
Stim IR - clump together and plug the hole
Stored in spleen
Platelets - Blood cells
Destroys old or imperfect RBCs
Breaks down the hemoglobin
Something wrong increased risk of bleeding
Stores platelets
Antibody production and filters antigens
After a splenectomy patients have reduced immune functions - increased risk for infection; decreased antibody production and ability filter them
Spleen - Accessory organs of blood formation
Produces prothrombin and other blood clotting factors
Assists in the forming of Vitamin K in the intestines - clotting
Stores all blood cells
Stores iron in the form of ferritin
Liver - Accessory organs of blood formation
Decreased blood volume
Lower levels of plasma proteins
Bone Marrow produces less blood cells
Hemoglobin levels in men and women fall after middle age
Immune responses change
Hematologic changes associated with aging
Could be related to decrease in protein intake
Higher risk for infections, bleeding, edema
Lower levels of plasma proteins - Hematologic changes associated with aging
RBC and WBC counts decrease
Platelet counts do not change with age
Bone Marrow produces less blood cells - Hematologic changes associated with aging
Could be related to decrease in iron intake
Hemoglobin levels in men and women fall after middle age - Hematologic changes associated with aging
WBC counts may be lower
WBC count does not rise as high in response to infection in older adults - not as responsive
Presentation of infection diff
Antibody levels and responses are lower and slower in older adults
Lymphocytes become less reactive to antigens
Immune responses change - Hematologic changes associated with aging
Patient history
Nutritional status - iron and vitamin B12
Environmental exposure - toxin
Family history and genetic risk
Current health problems
Assessment methods
Age - older
Gender
Liver function - symp liver disease, alcohol use
Presence of known immunologic or hematologic disorders
Drug use
Patient history
Females have lower red blood cells - H/H; worse when menstruating; worse fluid retention
Gender
Some medications can cause bone marrow suppression, hemolysis, or disrupt platelet action or clotting factors
Drug use
Many disorders are inherited
Ex. Sickle cell, hemophilia
Family history and genetic risk