Cardiovascular Physiology Flashcards
What is ANP (atrial natriuretic peptide) released in response to?
Increased atrial pressure
How many liters of blood per minute is pumped in a 70kg man
5-6 liters
What is BNP (b-type natriuretic peptide) released in response to?
overstretched ventricles
Intercalated discs allow the heart to contract in synchrony as one unit, what is this called?
Syncytium
What is happening with the ions in the initial repolarization in cardiac muscle contraction?
Inactivation of Na+ influx
K+ efflux
What is happening in the plateau phase of the cardiac muscle contraction? (ions)
Ca++ influx through L-type Ca++ channels
What determines the force of contraction of the myocardial cell?
The amount of intracellular calcium
No action potential can be initiated regardless of the stimulus strength, what refractory period is this?
Absolute refractory period
An action potential can be elicited, however a greater stimulus is needed, what refractory period is this?
Relative refractory period
Why is cardiac muscle incapable of sustained contraction (tetany) as in skeletal muscle?
Because of the relatively long refractory period
What is the Frank-Sterling law?
Cardiac output is directly proportional to venous return
The 1st heart sound is due to what?
Closure of the tricuspid and mitral valves
The 2nd heart sound is due to what?
Closure of the pulmonary and aortic valves
3rd heart sound occurs when?
After the 2nd heart sound and is seen in congestive heart failure
The 4th heart sound is heard when?
Before the 1st heart sound and is seen in hypertrophic ventricles
Systole (contraction) occurs between which heart sounds?
1st and 2nd
Diastole (relaxation) occurs between which heart sounds?
2nd and 1st
If there is a prolonged PR interval (>200 milliseconds)
1st degree AV block
If there is progressive prolongation of the PR interval with dropped beats
2nd degree AV block (Mobitz 1- Wenckebach phenomenon)
Isovolumic contraction occurs when?
Between the closure of the AV valves and the opening of the aortic valve
Increase in pressure without change in volume is called what?
Isovolumic contraction
What is it called when only 70ml of the 120ml of blood is expelled from the ventricle?
Ejection fraction