Cancer Virology Flashcards
1
Q
how do viruses cause cancer?
A
- integrations that alter oncogenes/tumor suppressors or components of signal transduction pathways
- chronic activation of the inflammatory response
2
Q
human papillomavirus (HPV) structure
A
naked, icosahedral
3
Q
human papillomavirus (HPV) & malignancy
A
viral proteins E6 and E7 INHIBIT tumor-suppressor genes p53 and Rb
4
Q
human papillomavirus (HPV) clinical course
A
*WARTS
*cervical cancer
5
Q
human papillomavirus (HPV) vaccine
A
Gardasil
6
Q
Merkel cell virus
A
causes SKIN cancer
7
Q
human T-lymphotropic virus (HTLV-1)
A
causes LEUKEMIA
8
Q
hepatocellular carcinoma - viral causes
A
Hep B and/or Hep C