cáncer de vesícula Flashcards

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1
Q

epidemio

A

aumento de incidencia en países desarrollados
3% de las neoplasias digestivas
Mayor prevalencia en América del sur, India, Pakistán y Europa central.

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2
Q

tipos de tumores biliares

A
  1. Colangiocarcinoma intra y extrahepático
  2. Cancer de la vesícula biliar
  3. Tumores de la ampolla de Vater (ampuloma).
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3
Q

COLANGIOCARCINOMA INTRAHEPÁTICO

A

se produce en las partes de los conductos biliares dentro del hígado

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4
Q

COLANGIOCARCINOMA EXTRAHEPÁTICO

A

tumores que crecen en los conductos biliares fuera del hígado.
90%

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5
Q

tipos de CC extrahepático

A

Colangiocarcinoma hiliar/ tumor Klatskin y Colangiocarcinoma distal

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6
Q

Manifestaciones clínicas

A

los síntomas dependen de la zona de la lesión
ictericia sin dolor, prurito, dolor abdominal, cólico biliar (esp. CVB), colangitis, hipocolia, coluria, fiebre, anorexia y pérdida ponderal.

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7
Q

factores de riesgo

A

litos –> colelitiasis –> inflamación. –> ⬆️riesgo

fumar
sexo: >mujeres
predisposición genética

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8
Q

marcadores tumorales

A

Niveles elevados en sangre de marcadores CEA y CA 19 - 9

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9
Q

GENES IMPLICADOS

A

K-ras
P53
PIK3CA
ErbB2 y ErbB3

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