CAD meds Flashcards
what drug classification is Atorvastatin (Lipitor)
HMG-CoA reductase inhibitor
pham action of statins
increase HDL
decrease LDL/VLDL & total cholesterol by inhibiting HMG CoA reductase (enzyme that makes cholesterol in the liver)
adverse drug reactions of statins
myopathy - pain in muscles that can lead to rhabdomyolysis (breakdown of muscle protein that can lead to kidney damage)
hepatotoxicity
what to monitor for statins
CK if muscle pain
liver function tests
contraindications of statins
teratogenic
liver dx
young kids
what drug classification is gemfibrozil, fenofibrate, or fenofibric acid
fibrate
pharm action of fibrates
increase HDL
mod decrease of LDL/VLDLs
adverse drug reaction of
Gi issues
Gallstones
Myopathy
hepatotoxicity
contraindications for fibrates
gall bladder dx
liver dysfxn
severe renal impairement
pharm action of nitroglycerin
vascular smooth muscle dilation
venous dilation of cardiac preload which decreases force required to contract
decreases oxygen demand of heart
relax angina spasms
adverse effects of nitroglycerin
headaches
orthostatic hypotension
tachycardia
tolerance
contraindications for nitroglycerin
teratogenic
increased cranial pressure
severe anemia
constrictive pericarditis
uncorrected hypovolemia
pharm action of Na channel blockers
slow down electric signals
reduce transition of pain signals
what are classification of quinidine and procainamide
sodium channel blockers
adverse effects of quinidine & procainamide
GI issues
tachycardia
hypotension
widen QRS and prolonged QT
shock with rapid infusion
lupus with long-term therapy
cinchonism (tinnitus, visual, headache, N&V)
contraindications with sodium channel blockers
severe heart block (slow pulse)
torsades de pointes dysrhythmia (twisting of points on ECG)
what class is lidocaine
sodium channel blocker
adverse drug reaction of lidocaine
CNS
hypotension, bradycardia, heart block in high doses
contraindications for lidocaine
supraventricular dysrhythmias
untreated bradycardia/heart block
what class do flecainide and propafenone go
sodium channel blockers
nitroglycerin when to give sublingual PO or patch
PO for stable and predicable
patch for unstable and random
when to call 911 on nitroglycerine
pain after 5 mins 1st dose
max dose 3 in 5 mins intervals
function of statins
lower bad lipids
increase good lipids HDL
reduce likelihood of MI
side effects of statins
STAT accronym
S: sore muscles
T: toxic liver
A: avoid grapefruit & St. John’s wort
T: take at night
