BS: Inflammation Flashcards
Arachidonic acid products (Vasodilation)
Prostaglandins (PGI2, PGE1, PGE2, and PGD2)
Arachidonic acid products (Vasoconstriction)
Thromboxane A2, Leukotrienes C4, D4, and E4
Arachidonic acid products (Increased vascular permeability)
Leukotrienes C4, D4, and E4
Arachidonic acid products (chemotaxis, leukocyte adhesion)
Leukotrienes B4, Hydroxyelcosatetraenoic acid (HETE)
Histamine (source)
mast cells, basophils, platelets
Histamine (action)
vasodilation, increased vascular permeability, endothelial activation
important in acute inflammatory response
Prostaglandins (source)
mast cells, leukocytes
Prostaglandins (action)
vasodilation, pain, fever
important in acute inflammatory response
Leukotrienes (source)
mast cells, leukocytes
Leukotrienes (action)
Increased vascular permeability, chemotaxis, leukocyte adhesion, and activation
important in acute inflammatory response
Chemokines (source)
Leukocytes, activated macrophages, endothelial cells, T-lymphocytes, mast cells
Chemokines (action)
Chemotaxis, leukocyte activation; recruitment of leukocytes to site of activation, migration of cells in normal tissues
Platelet-activating factor (source)
Leukocytes, mast cells
Platelet-activating factor (action)
Vasodilation, increased vascular permeability, leukocyte adhesion, chemotaxis, degranulation, oxidative burst
Complement (source)
plasma (produced in liver)
Complement (action)
Leukocyte chemotaxis and activation, direct target killing (membrane attack complex), vasodilation (mast cell stimulation)
Kinins (source)
plasma (produced in liver)
TNF (source)
macrophages, mast cells, T-lymphocytes
TNF (action)
acute inflammation
stimulates expression of endothelial adhesion molecules and secretion of other cytokines; systemic effects
IL-1 (source)
macrophages, endothelial cells and some epithelial cells
IL-1 (action)
acute inflammation
stimulates expression of endothelial adhesion molecules and secretion of cytokines; large role in the production of fever
IL-6 (source)
Macrophages, other cells
IL-6 (action)
acute inflammation
systemic effects
IL-17 (source)
T Lymphocytes
IL-17 (action)
acute inflammation
recruitment of neutrophils and monocytes
IL-12 (source)
dendritic cells, macrophages
IL-12 (action)
chronic inflammation
increased production of IFN-Y
IFN-Y (source)
T lymphocytes, NK cells
IFN-Y (action)
chronic inflammation
activation of macrophages (increased ability to kill microbes and tumor cells)
IL-17 (source)
T lymphocytes
IL-17 (action)
chronic inflammation
recruitment of neutrophils and monocytes
Chronic Inflammation Cytokines
IL-12, IFN-Y, IL-17
Acute Inflammation Cytokines
TNF, IL-1, IL-6, IL-17 and chemokines
