bone overview/basics Flashcards
functions of bone
support - framework and shape of body
protection - surrounds major internal organs and vasculature
locomotion - joints allow flexibility and attachment site of muscles
haematopoesis - reservoir of stem cells forming blood cells
lipid and mineral storage - adipose tissue stored within bone marrow and calcium within hydroxyapatite crystals
different types of bone
flat bones - protect organs
long bones - support and facilitate movement
irregular bones - vary in shape and structure
short bones - provide stability and some movement
sesamoid bone - embedded within tendons and protect them from stress/wear
what is primary/woven bone?
first type of bone to be formed - in embryonic dev and fracture healing
consists of osteoid, randomly arranged collagen fibres
temporary structure replaced by mature lamellar bone
what is lamellar/secondary bone
bone of adult skeleton
highly organised sheets of mineralised osteoid, making it stronger than woven bone
can be divided into: compact or spongy
what is compact/cortical bone
found in diaphysis, forms outer part of bone
organised in concentric circles around haversian canal
haversian canal are connected by volkmanns canals which contain small vessels that also supply periosteum
what is spongy/cancellous bone
found in epiphysis, irregular crosslinking of trabeculae to form porous yet strong bone resistant against multidirectional lines of force
large spaces between tabeculae give it honeycomb appearance - contains red bone marrow
ecm provides biomechanical and structural support containing:
collagen - 90% type 1 and some type 5
mineral salts - calcium hydroxyapatite
calcification of bone occurs when mineral salts interpose between collagen fibres
2 ways bone can grow:
endochondral: formation of bone onto temporary cartilage scaffold e.g hyaline cartilage replaced by osteoblasts secreting osteoid in femur
+ provides length
intramembranous: formation of bone directly onto fibrous connective tissue e.g temporal bone/scapula
provides width to bone
what is osteoporosis
decrease in bone density, reducing structural integrity
osteoclast>osteoblast
what is rickets/osteomalacia
vit d/ calcium deficiency in children
what is osteogenesis imperfecta
abnormal synthesis of bone
increased fragility of bones, bone deformity and blue sclera
what is a fracture
discontinuity of bone
what is primary/ direct bone healing
intramembranous healing, occurs via haversian canals
slow process
secondary/indirect healing
endochondral healing involves responses in periosteum and external soft tissues
fast process resulting in callus formation (fibrocartilage)
what are the prerequisites for healing
minimal fracture gap
no movement if direct bony healing or some movement if indirect bone healing
patient physiological state - nutrients, growth factors, age, diabetic,smoker