BMB 1 - Brainstem Nuclei & Tracts Flashcards

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1
Q

Identify the three major portions of the brainstem in this image.

A
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2
Q

What are the three longitudinal portions of the brainstem?

A

Basis (basement - dark gray)

Tegmentum (floor - light gray)

Tectum (roof - labeled)

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3
Q

Which longitudinal tract of the brainstem contains tracts from the cortex (especially the corticospinal)?

A

The basis (basement - dark gray)

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4
Q

The tegmentum of the brainstem (the light gray) contains which cranial nerve nuclei?

A

III - XII

(all but I and II)

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5
Q

What structures are associated with the tectum?

A

Midbrain integrative structures - e.g. center for vision (superior colliculus) or hearing (inferior colliculus)

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6
Q

Identify the cranial nerves which emerge from the midbrain.

A

CN III and IV

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7
Q

Identify the cranial nerves which emerge from the pons.

A

V, VI, VII, VIII

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8
Q

Identify the cranial nerves which emerge from the medulla.

A

IX, X, XI, and XII

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9
Q

Which cranial nerves exit ventrally?

Which cranial nerves exit dorsally?

A

All but IV;

IV only

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10
Q

Where does the trochlear nerve exit the midbrain?

A

Dorsally; inferior to the inferior colliculus

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11
Q

Where does the trigeminal nerve exit the brainstem?

A

Near the middle cerebellar peduncle

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12
Q

Where does the abducens nerve exit the brainstem?

A

Medially; along the pontomedullary junction

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13
Q

Where does the facial nerve exit the brainstem?

A

Along the pontocerebellar junction;

lateral to CN VI

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14
Q

Where does the vestibulocochlear nerve exit the brainstem?

A

Along the pontocerebellar junction;

lateral to CN VII

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15
Q

Where does the glossopharyngeal nerve exit the brainstem?

A

The groove dorsal to the olive in the postolivary sulcus

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16
Q

Where does the vagus nerve exit the brainstem?

A

The groove dorsal to the olive in the postolivary sulcus

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17
Q

Where does the accessory nerve exit the brainstem?

A

It does not;

it exits the cervical spinal cord (not technically a cranial nerve)

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18
Q

Where does the hypoglossal nerve exit the brainstem?

A

Between the pyramid and the olive (in the pre-olivary sulcus)

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19
Q

In what structures do the dorsal columns end?

A

The gracile and cuneate tubercles

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20
Q

Of the cerebellar peduncles, which provide the major input to the cerebellum?

A

The middle cerebellum peduncles

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21
Q

Of the cerebellar peduncles, which provide the major output from the cerebellum?

A

The superior and inferior cerebellar peduncles

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22
Q

From caudal to rostral, what are the four main parts of the internal organization of the brainstem?

A

Closed medulla >

Open medulla >

Pons >

Midbrain

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23
Q

Of the four main parts of the internal organization of the brainstem (closed medulla, open medulla, pons, midbrain), in which do the fasciculus cuneatus and fasciculus gracilis terminate?

A

The closed medulla

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24
Q

This is a cross-section of what portion of the brainstem?

A

The closed medulla

(the otter)

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25
Q

This is a cross-section of what portion of the brainstem?

A

The open medulla

(the bulldog)

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26
Q

This is a cross-section of what portion of the brainstem?

A

The pons

(Snidely Whiplash)

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27
Q

This is a cross-section of what portion of the brainstem?

A

Midbrain

(the stingray)

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28
Q

What are the shape mnemonics for the four main parts of the internal brainstem organization as seen in cross-section?

Midbrain

Pons

Open medulla
Closed medulla

A

Stingray

Snidely Whiplash

Bulldog

Otter

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29
Q

In which of the four main parts of the internal brainstem organization does most sensory decussation occur (via the medial lemniscus pathway)?

Midbrain

Pons

Open medulla
Closed medulla

A

The closed medulla

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30
Q

Where are the nuclei gracilis and cuneatus in the brainstem?

A

The closed medulla

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31
Q

In which of the four main parts of the internal brainstem organization are the second-order sensory neuron cell bodies?

Midbrain

Pons

Open medulla
Closed medulla

A

The closed medulla

(the nucleus cuneatus and gracilis)

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32
Q

In which of the four main parts of the internal brainstem organization are the hypoglossal nuclei?

Midbrain

Pons

Open medulla
Closed medulla

A

The open medulla

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33
Q

In which of the four main parts of the internal brainstem organization is the inferior cerebellar peduncle?

Midbrain

Pons

Open medulla
Closed medulla

A

The open medulla

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34
Q

In which of the four main parts of the internal brainstem organization are the olives?

Midbrain

Pons

Open medulla
Closed medulla

A

The open medulla

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35
Q

The brainstem olive is connected to the cerebellum and helps facilitate _____________ movement.

A

The brainstem olive is connected to the cerebellum and helps facilitate pre-programmed movement.

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36
Q

In a cross-section of the pons (which looks like Snidely Whiplash), which part of the cross-section looks like a mustache way at the bottom of the section?

A

The ponto-cerebellar fibers

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37
Q

The substantia nigra and superior colliculi are both found in what section of the brain?

A

The midbrain

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38
Q

In cross-section of the midbrain (which looks like a stingray), describe where the superior colliculi and substantia nigra are.

A
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39
Q

Where (specifically) in the brain is the reticular formation found?

A

The tegmentum in all levels of the brainstem

40
Q

The _______ (rostral/caudal) portion of the reticular formation maintains an alert, conscious state in the forebrain.

A

The rostral portion of the reticular formation maintains an alert, conscious state in the forebrain.

41
Q

The _______ (rostral/caudal) portion of the reticular formation connects to cranial nerve and spinal nuclei and controls various motor, reflex, and autonomic functions.

A

The caudal portion of the reticular formation connects to cranial nerve and spinal nuclei and controls various motor, reflex, and autonomic functions.

42
Q

The reticulospinal tract aids in maintaining tone and balance and is a projection from what tegmental structure?

A

The caudal reticular formation

43
Q

A patient suffers a stroke leading to ischemia of their reticular formation.

What two major effects do you expect in particular?

A
  1. Loss of consciousness
  2. Impaired breathing
44
Q

Name the respective nuclei in the reticular formation that secrete each of the following:

Serotonin

Acetylcholine

Norepinephrine

Dopamine

A

Raphe magnus

Pedunculopontine

Locus ceruleus

Ventral tegmental area

45
Q

The pyramidal tracts in the brainstem are mainly involved in transmitting signals involved in what?

A

Motor control

(corticospinal and cerebellar functions)

46
Q

What is the purpose of the long tracts of the brainstem?

A

To connect the higher order cerebral structures to the spinal cord

47
Q

What are the three long tracts of the brainstem?

A
  1. The corticospinal
  2. The somatosensory (spinothalamic + medial lemniscus)
  3. The trigeminal system (chief sensory + trigeminothalamic)
48
Q

Describe how the corticospinal tracts travel through the brainstem.

A

(The majority of decussation occurring towards the caudal portion)

49
Q

Where do 90% of corticospinal fibers decussate (i.e. where does pyramidal decussation occur)?

A

The lower medulla

50
Q

The corticospinal fibers come from Brodmann area 4, travel through the ___________ of the midbrain, travel through the _____ pontis of the pons, and decussate at the lower medulla.

A

The corticospinal fibers come from Brodmann area 4, travel through the cerebral peduncle of the midbrain, travel through the basis pontis of the pons, and decussate at the lower medulla (to then become the _lateral_ corticospinal tract in the spinal cord).

51
Q

True/False.

The corticospinal tract travels mainly through the tegmentum of the brainstem (light gray).

A

False.

The corticospinal tract travels mainly through the ventral (basis) of the brainstem (dark gray area in previous image).

52
Q

What is the significance of the corticospinal tract mainly being in the basis (anterior portion) of the brainstem?

A

It is far from the vertebral and basilar arteries

(and thus extra susceptible to ischemic damage)

53
Q

The corticospinal tract is responsible for voluntary motor control and travels ipsilaterally through the brainstem, through the _______ _______ in the midbrain, the _______ _______ in the pons, and the _______ in the medulla.

A

The corticospinal tract is responsible for voluntary motor control and travels ipsilaterally through the brainstem, through the cerebral peduncle in the midbrain, the basal pons in the pons, and the pyramids in the medulla.

54
Q

Neurons of the lateral corticospinal tract synapse in the _______ _______ of the spinal tract.

A

Neurons of the lateral corticospinal tract synapse in the anterior horn of the spinal tract.

55
Q

The neurons that synapse directly on skeletal muscle and cause voluntary muscle contraction are ____ motor neurons.

A

The neurons that synapse directly on skeletal muscle and cause voluntary muscle contraction are α motor neurons.

56
Q

Why does brainstem ischemia often cause issues with voluntary motor control?

A

The blood supply is in the tegmentum (dorsal), and the corticospinal tract is in the basement (ventral)

57
Q

Damage to the corticospinal tract in the brainstem is most likely to lead to what motor S/Sy?

A

Upper motor neuron signs

  1. Babinski sign
  2. Spastic paralysis
  3. Contralateral hemiparesis
58
Q

Name the three S/Sy of upper motor neuron lesions.

A
  1. Babinski sign
  2. Spastic paralysis
  3. Contralateral hemiparesis
59
Q

Describe where in the cross-sections of the brainstem you would find the corticospinal tract.

Note: this includes the midbrain, pons, pontomedullary junction, open medulla, and closed medulla.

A
60
Q

Which are the two brainstem tracts that make up the somatosensory tract?

A

The spinothalamic and medial lemniscus

61
Q

The dorsal column first-order neurons synapse with second-order neurons in which nuclei?

And where do these second-order neurons synapse with third-order neurons?

A

The medulla nucleus gracilis and cunateus;

the thalamic VPL

62
Q

Second-order neurons in both the spinothalamic and medial lemniscus tracts synapse on third-order neurons in what nucleus?

A

The ventral posterolateral nucleus

(the thalamic VPL)

63
Q

How can one check the integrity of the dorsal column - medial lemniscus system?

A

The Romberg test

64
Q

True/False.

The nucleus gracilis and nucleus cunateus are located in the pons.

A

False.

The nucleus gracilis and nucleus cunateus are located in the medulla.

65
Q

True/False.

The ventral posteromedial and ventral posterolateral nuclei are located in the pons.

A

False.

The ventral posteromedial and ventral posterolateral nuclei are located in the thalamus.

66
Q

In the pons and midbrain, secondary neurons of the medial lemniscus are _______ (medial/lateral/ventral/dorsal) to secondary neurons of the anterolateral system (spinothalamic tract).

A

In the pons and midbrain, secondary neurons of the medial lemniscus are medial to secondary neurons of the anterolateral system (spinothalamic tract).

67
Q

What sensory information is carried by the dorsal columns - medial lemniscus pathway?

A
  1. Discriminatory touch
  2. Conscious proprioception
  3. Vibration
68
Q

What sensory information is carried by the spinothalamic pathway?

A
  1. Pain
  2. Itch and tickle
  3. Crude touch

(strong stimulus needed)

69
Q

Where do first-order neurons of the spinothalamic tract decussate and synapse?

Where do second-order neurons of the spinothalamic tract synapse?

A

The nucleus proprius; the anterior white commissure;

the thalamic ventral posterolateral nucleus

70
Q

Describe the pathways of the medial lemniscus and spinothalamic tracts through the brainstem.

A
71
Q

Describe the locations of the medial lemniscus and spinothalamic tracts on cross-section of the closed medulla.

A
72
Q

Describe the post-decussation pathway of the medial lemniscus as seen on cross-section of the open medulla, pons, midbrain, and inferior colliculus.

A
73
Q

Describe the locations of the medial lemniscus and spinothalamic tracts on cross-section of the open medulla, pons, and midbrain.

A
74
Q

The brainstem trigeminal system consists of two tracts: the _____________, which carries discriminatory sensation from the face, and the _____________, which carries pain and temperature sensation from the face.

A

The brainstem trigeminal system consists of two tracts: the chief sensory, which carries discriminatory sensation from the face, and the trigeminothalamic, which carries pain and temperature sensation from the face.

75
Q

The chief sensory tract (CN V) synapses in the ___________ nucleus, and the trigeminothalamic tract (CN V) synapses in the ___________ nucleus.

A

The chief sensory tract (CN V) synapses in the chief sensory nucleus, and the trigeminothalamic tract (CN V) synapses in the spinal tract of V nucleus.

76
Q

Which thalamic nucleus carries sensory information from the body?

Which thalamic nucleus carries sensory information from the face?

A

The ventral posterolateral nucleus;

the ventral posteromedial nucleus

77
Q

True/False.

The chief sensory tract (CN V) synapses in the chief sensory nucleus, decussates, synapses in the ventral posterolateral nucleus of the thalamus, and then continues to the cortex.

A

True.

78
Q

True/False.

The trigeminothalamic tract (CN V) synapses in the chief sensory nucleus, synapses in the ventral posterolateral nucleus of the pons, decussates, and then continues to the cortex.

A

True/False.

The trigeminothalamic tract (CN V) synapses in the spinal nucleus of V, decussates, synapses in the ventral posteromedial nucleus of the thalamus, and then continues to the cortex.

79
Q

The chief sensory tract (CN V) carries what type of information from the face?

The trigeminothalamic (CN V) carries what type of information from the face?

A

Discriminatory sensation;

pain and temperature

80
Q

Describe the location of the spinal nucleus of V in the closed medulla in relation to the medial lemniscus pathways.

A
81
Q

Describe the locations of the spinal tract of V in the open medulla, pons, pontomedullary junction, and midbrain.

A
82
Q

Which tracts intrinsic to the brainstem are found in the superior colliculus?

A

Tectospinal and spinotectal tracts

83
Q

What is the function of the superior colliculus?

A

To mediate reflex turning of head and neck in response to visual stimuli

84
Q

Identify the portions of the midbrain indicated by arrows.

A
85
Q

What is the function of the inferior colliculus?

A

To receive auditory information from the lateral lemniscus and relays to thalamus

86
Q

What is the function of the periaquaductal grey matter?

A

To modulate pain signals to the spinal cord substantia gelatinosa

87
Q

Which two large structures receive output from cerebellum and sends fibers back to the cerebellum?

What tract projects from these structures to the anterior horn of the spinal cord in order to control contralateral distal musculature?

A

The red nuclei;

the rubrospinal tracts

88
Q

Where is the substantia nigra located?

What two tracts project from the substantia nigra?

A

The ventral tegmentum of the midbrain;

nigrostriatal and striatonigral tracts

89
Q

If you can see the superior colliculus on a cross-section of the midbrain, will the red nuclei be visible?

If you can see the inferior colliculus on a cross-section of the midbrain, will the red nuclei be visible?

A

Yes;

no

90
Q

Where do nerve fibers to and from the cerebellum (an ipsilateral system) decussate before reaching the cortex (a contralateral system)?

A

The pontocerebellar fibers (entering the cerebellum at the middle cerebrellar peduncle);

the superior cerebellar penducle (exiting the cerebellum)

91
Q

Name two structures found within the basis pontis.

A

The superior olivary nucleus and lateral lemniscus

92
Q

The middle cerebellar peduncle is found in what portion of the brainstem?

The inferior cerebellar peduncle is found in what portion of the brainstem?

A

The pons;

the open medulla

93
Q

The ________ cerebellar peduncle is responsible for unconscious proprioception, coordination, and balance. Damage to this structure is often due to stroke of vertebral artery or PICA and results in swaying or staggering to the _____lateral side.

A

The inferior cerebellar peduncle is responsible for unconscious proprioception, coordination, and balance. Damage to this structure is often due to stroke of vertebral artery or PICA and results in swaying or staggering to the ipsilateral side.

94
Q

Name the portions of the reticular system responsible for each of the following:

(1) Reward, arousal, consciousness, and sleep
(2) Breathing
(3) Balance, posture, axial control
(3) Cardiac function

A

(1) Ascending reticular activation system
(2) Respiratory centers
(3) Reticulospinal pathway
(4) Cardiac control center

95
Q

True/False.

Damage to the hypothalamospinal tracts (e.g. in the reticular system) can lead to Horner’s syndrome.

A

True.