Block3neoplasm2

Question 1

Small cell cancer of the lung, ACTH secretion, what disease will there be?

Answer 1

Cushing’s Syndrome

Question 2

What is the most common syndrome squamos cell cancer of the lung, hypercalcemia?

Answer 2

PTHrP Parathyroid related hormone, also found in breast cancer

Question 3

What is small cell carcinoma of the lung, intracranial tumors via ADH?

Answer 3

SIADH

Question 4

Carcinoid syndrome which has pancreatic carcinoma, gastric carcinoma is what neurotransmitter?

Answer 4

Serotonin

Question 5

Venous thrombosis/Trosseau’s Syndrome is what?

Answer 5

Tumor in veins, thrombophlebitis

Question 6

Hypertrophic Osteoarthropathy causes what?

Answer 6

Clubbing of digits

Question 7

Dermatological disorders, Acanthosis nigrans: is what?

Answer 7

Gastric carcinoma, lung cancer

Question 8

Dermatomyositis, is a dermatological disorder that is what?

Answer 8

Bronchogenic Carcinoma or lung cancer

Question 9

Grading is based on the degree of what?

Answer 9

Differentiation (1-4)

Question 10

What is based on a scale of extent of local and distant spread (invasion)?

Answer 10

Staging

Question 11

What is the staging T, what is the staging N, what is the M?

Answer 11

Primary Tumor T(1-4)
Lymph Node (N0-N3)
Metastasis (M1-M0)

Question 12

What test looks at the warburg test?

Answer 12

PET, the cells are glucose hungry

Question 13

What is fine needle aspiration cytology?

Answer 13

Aspiration of cells and fluid from the tumor?

Question 14

What is a pap smear, looks at shed cells from the cervix and stomach?

Answer 14

Exfoliative cytology

Question 15

What is the most useful method in detecting genetic alterations?

Answer 15

DNA microarrays

Question 16

What DNA microarray is used to map/cover an entire genome?

Answer 16

Tiling arrays

Question 17

What technique looks at translocations t(9:22)?

Answer 17

FISH

Question 18

PCR looks for what?

Answer 18

mutations and translocations, monoclonal and polyclonal lymphocytic proliferation

Question 19

What is the gold standard technique for molecular studies looking for clonality? Looking for X-chromosome inactivation?

Answer 19

Southern Blot and PCR

Question 20

What is the DNA content of tumor cells?

Answer 20

Ploidy

Question 21

What is routinely used to diagnosis lymphomas and leukemias?

Answer 21

Flow Cytometery

Question 22

Hepatocellular carcinoma, nonseminomatous testicular germ-cell tumors, Yolk sac tumor, normally made in a fetus, has what marker?

Answer 22

Alpha-fetoprotein (AFP)

Question 23

What is prostate cancer, elevated in BPH and Prostitis?

Answer 23

PSA prostate specific antigen

Question 24

What is elevated in colorectal cancer, carcinomas of the lung, pancreas, stomach, colon, and breast?

Answer 24

CEA: carcinoembryonic antigen

Question 25

What is elevated in the medullary carcinoma of the thyroid?

Answer 25

Calcitonin

Question 26

What disease has an elevated CA-125 tumor marker?

Answer 26

Ovarian Cancer

Question 27

What marker is elevated with pancreatic cancer, colon cancer?

Answer 27

CA 19-9

Question 28

What is elevated in Seminoma, tumor marker?

Answer 28

Placental alkaline phosphate

Question 29

What is elevated in hydatidiform moles, choriocarcinomas, and trophoblastic tumors?

Answer 29

Beta human Chorionic gonadotropin (hCG)

Question 30

What is elevated in melanoma, neural tumors, astrocytomas?

Answer 30

S-100

Question 31

What is elevated in metastases to bone, obstructive biliary disease, paget’s disease in bone?

Answer 31

Alkaline phosphate

Question 32

What is the MEN syndrome causing an increase in? What are the three types of tumors?

Answer 32

multiple endocrine tumors

Pituitary Tumors, Parathyroid Adenomas, Pancreatic Tumor