Block3

Question 1

What does c-myc contribute towards?

Answer 1

Burkitts Lymphoma

Question 2

What does BCl-2 contribute towards?

Answer 2

Follicular and Undifferentiated lymphomas

Question 3

What does RAS contribute towards?

Answer 3

colon cancer

Question 4

What does ERB-B2 contribute towards?

Answer 4

Breast, Ovarian, Lung, and gastric cancer

Question 5

What dos cyclin D contribute towards?

Answer 5

Mantle Cell lymphoma

Question 6

What does N-myc contribute towards?

Answer 6

Neuroblastoma

Question 7

What does RET contribute towards?

Answer 7

MEN, multiple endocrine neoplasia

Question 8

What does ABL contribute towrads?

Answer 8

CML, ALL –> chronic myelogenous leukemia, oncogene, not sure what ALL stands for

Question 9

What does PDGFRA contribute towards?

Answer 9

Astrocytoma

Question 10

What does ERBB1 contribute towards?

Answer 10

Squamous Cell Carcinoma

Question 11

What does Small cell carcinoma contribute towards?

Answer 11

L-myc

Question 12

What does Breast cell carcinoma contribute towards?

Answer 12

erb-B3

Question 13

What does the RB gene contribute towards?

Answer 13

Retinoblastoma, osteosarcoma, this is a tumor suppressor gene

Question 14

What does the APC gene contribute towards?

Answer 14

familial polyposis of colon, this is a tumor suppressor gene

Question 15

Lack of P53 is what?

Answer 15

Li Fraumani Syndrome, this is a tumor suppressor gene

Question 16

What is WT-1?

Answer 16

Wilts tumor, this is a tumor suppressor gene

Question 17

What is E-cadherin?

Answer 17

Lobular cancer of the breast, this is a tumor suppressor gene

Question 18

When there is a loss of the APC gene, what results and what transcription factor is not regulated?

Answer 18

B-catenin

Question 19

P53 is on what chromosome?

Answer 19

17th Chromosome

Question 20

What can deactivate p53 from viral proteins?

Answer 20

E6 from HPV

Question 21

What does NF-2 code for?

Answer 21

Merlin, look for with schwannomas

Question 22

What does SMAD2/4 cause if bad?

Answer 22

Mutated in familial juvenile polyposis

Question 23

What chromosome does Retinoblastoma come from?

Where does BRCA 1 and 2 orginate?

Answer 23

13

17 and 13

Question 24

What does WT1 push towards?

Answer 24

transcription factor for genes involved in renal and gonadal diff.

Question 25

What does the von Hippel Lindau gene, if bad, cause tumors?

Answer 25

Renal cell Cancer, Angioblastic tumor of CNS

Question 26

What does phosphatase and tensin mutated cause? What does PTEN normally inhibit?

Answer 26

PTEN can cause cancer and gilobastoma PI3K/AKT

Question 27

What can DNA methylation turned off in GI cancers, considered a gastrointestinal cancer?

Answer 27

p14/ARF

Question 28

Cystosarcoma phyllodes of breast Dermatofibrosarcoma protruberance What are these popular for?

Answer 28

These are the two benign sarcomas

Question 29

What is IL-6 mitogenic used for what?

Answer 29

Spindle Cells

Question 30

What is IL-8 mitogenic used for what?

Answer 30

Endothelial Cells

Question 31

What is the most common tumor?

Answer 31

Basal Cell Carcinoma, 2nd place is squamous cell

Question 32

Insulin like growth factor: ovarian carcinoma, fibrosarcoma, can cause what?

Answer 32

hypoglycemia

Question 33

What does asbestos cause?

Answer 33

Mesothelioma

Question 34

What does vinyl chloride cause?

Answer 34

Liver angiosarcoma

Question 35

What does benzene cause?

Answer 35

Leukemia

Question 36

What does radium cause?

Answer 36

Lung Cancer

Question 37

What does arsenic cause?

Answer 37

Skin cancer and hemangiosarcoma

Question 38

What does polycyclic aromatic hydrocarbons cause from smoking?

Answer 38

Lung and Bladder cancer?

Question 39

What does Alfatoxin B1 from aspergillus cause?

Answer 39

Hepatocellular carcinoma

Question 40

What disease causes an increase in serotonin, implicating pancreatic or gastric cancer?

Answer 40

Carcinoid Syndrome