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S&D1 > Block3 > Flashcards

Block3 Flashcards

1
Q

What does c-myc contribute towards?

A

Burkitts Lymphoma

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2
Q

What does BCl-2 contribute towards?

A

Follicular and Undifferentiated lymphomas

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3
Q

What does RAS contribute towards?

A

colon cancer

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4
Q

What does ERB-B2 contribute towards?

A

Breast, Ovarian, Lung, and gastric cancer

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5
Q

What dos cyclin D contribute towards?

A

Mantle Cell lymphoma

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6
Q

What does N-myc contribute towards?

A

Neuroblastoma

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7
Q

What does RET contribute towards?

A

MEN, multiple endocrine neoplasia

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8
Q

What does ABL contribute towrads?

A

CML, ALL –> chronic myelogenous leukemia, oncogene, not sure what ALL stands for

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9
Q

What does PDGFRA contribute towards?

A

Astrocytoma

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10
Q

What does ERBB1 contribute towards?

A

Squamous Cell Carcinoma

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11
Q

What does Small cell carcinoma contribute towards?

A

L-myc

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12
Q

What does Breast cell carcinoma contribute towards?

A

erb-B3

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13
Q

What does the RB gene contribute towards?

A

Retinoblastoma, osteosarcoma, this is a tumor suppressor gene

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14
Q

What does the APC gene contribute towards?

A

familial polyposis of colon, this is a tumor suppressor gene

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15
Q

Lack of P53 is what?

A

Li Fraumani Syndrome, this is a tumor suppressor gene

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16
Q

What is WT-1?

A

Wilts tumor, this is a tumor suppressor gene

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17
Q

What is E-cadherin?

A

Lobular cancer of the breast, this is a tumor suppressor gene

18
Q

When there is a loss of the APC gene, what results and what transcription factor is not regulated?

A

B-catenin

19
Q

P53 is on what chromosome?

A

17th Chromosome

20
Q

What can deactivate p53 from viral proteins?

A

E6 from HPV

21
Q

What does NF-2 code for?

A

Merlin, look for with schwannomas

22
Q

What does SMAD2/4 cause if bad?

A

Mutated in familial juvenile polyposis

23
Q

What chromosome does Retinoblastoma come from?

Where does BRCA 1 and 2 orginate?

A

13

17 and 13

24
Q

What does WT1 push towards?

A

transcription factor for genes involved in renal and gonadal diff.

25
Q

What does the von Hippel Lindau gene, if bad, cause tumors?

A

Renal cell Cancer, Angioblastic tumor of CNS

26
Q

What does phosphatase and tensin mutated cause?

What does PTEN normally inhibit?

A

PTEN can cause cancer and gilobastoma

PI3K/AKT

27
Q

What can DNA methylation turned off in GI cancers, considered a gastrointestinal cancer?

A

p14/ARF

28
Q

Cystosarcoma phyllodes of breast
Dermatofibrosarcoma protruberance
What are these popular for?

A

These are the two benign sarcomas

29
Q

What is IL-6 mitogenic used for what?

A

Spindle Cells

30
Q

What is IL-8 mitogenic used for what?

A

Endothelial Cells

31
Q

What is the most common tumor?

A

Basal Cell Carcinoma, 2nd place is squamous cell

32
Q

Insulin like growth factor: ovarian carcinoma, fibrosarcoma, can cause what?

A

hypoglycemia

33
Q

What does asbestos cause?

A

Mesothelioma

34
Q

What does vinyl chloride cause?

A

Liver angiosarcoma

35
Q

What does benzene cause?

A

Leukemia

36
Q

What does radium cause?

A

Lung Cancer

37
Q

What does arsenic cause?

A

Skin cancer and hemangiosarcoma

38
Q

What does polycyclic aromatic hydrocarbons cause from smoking?

A

Lung and Bladder cancer?

39
Q

What does Alfatoxin B1 from aspergillus cause?

A

Hepatocellular carcinoma

40
Q

What disease causes an increase in serotonin, implicating pancreatic or gastric cancer?

A

Carcinoid Syndrome

S&D1 (17 decks)

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