blistering disorders

Question 1

Bullous pemphigoid-Eti

Answer 1

Bullous autoimmune disorder in elderly- 60 onset, men more frequently.

Question 2

Bullous pemphigoid- Sx

Answer 2

Prodrome followed by bullae in a generalized eruption. Moderate to severe pruritus. Erythematous, small, tense lesion in flexural areas- containing serous or hemorrhagic fluid.

Question 3

Bullous pemphigoid- Dx

Answer 3

Antibody test or biopsy

Question 4

Bullous pemphigoid- Tx

Answer 4

Ultra potent topical corticosteroids. Systemic predisone if severe

Question 5

Pemphigus vulgaris- Eti

Answer 5

Autoimmune disorder- rare, most common in jewish or Mediterranean descent. Onset 40-60 YO

Question 6

Pemphigus vulgaris- Sx

Answer 6

Lesions begin on oral mucous membranes. Flaccid bullae turn to crusts and erosions. Painful.

Question 7

Pemphigus vulgaris- Dx

Answer 7

IgG antibodies in serum. Light microscopy. Niklosky sign- rubbing swab on uninvolved skin causes separation

Question 8

Pemphigus vulgaris- Tx

Answer 8

Glucocorticoids & immunosuppresive therapy. Agressive tx required