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K2 - Bevægeapparatet og bloddannende organer > Bindevævssygdomme > Flashcards

Bindevævssygdomme Flashcards

1
Q

Angiv fællestræk for bindevævssygdomme

A

symptomer

  • artralgi/artrit
  • Raynauds fænomen
  • Muskelsvækkelse
  • Udslæt

undersøgelser

  • ANA, andreautoantistoffer
  • Biopsiafafficeret væv

Behandling

  • Symptomlindrende
  • Evt.immunhæmmende
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2
Q

Nævn eksempler på bindevævssygdomme

A
  • Systemisklupuserythematosus(SLE)
  • Systemisksclerose/sklerodermi
  • Mixedconnective tissuedisease(MCTD)
  • Sjögrenssyndrom
  • Dermato-/polymyositis (DM/PM)
  • Vasculitissyndromer
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3
Q

Systemisksklerodermi

angiv prævalens

A
  1. pr. 100.000
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4
Q

Systemisksklerodermi

aldersgruppe?

A

30-60 år

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5
Q

Systemisksklerodermi

kønsfordeling?

A

4:1 kvinde vs. mænd

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6
Q

Systemisksklerodermi

definition?

A

karforandringer + fibrose i hud/organer

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7
Q

Systemisksklerodermi

angiv manifestationer?

A
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8
Q

Systemisksklerodermi

nævn klassifikationskriterier

A
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9
Q

Systemisksklerodermi

behandling?

A
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10
Q

Mixed connective tissue disease (MCTD)

hvad kaldes denne her sygdom også?

A

“lillesøster”-sygdom til SLE og systemisk sklerodermi

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11
Q

Mixed connective tissue disease (MCTD)

definition?

A

–Raynauds fænomen

–Daktylitis(pølsefingre)

–Artrit

  • RNP-antistoffer (Obligatorisk)
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12
Q

Mixed connective tissue disease (MCTD)

prævalens?

A
  1. pr. 100.000
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13
Q

Mixed connective tissue disease (MCTD)

kønsfordeling?

A

90% kvinder

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14
Q

Mixed connective tissue disease (MCTD)

aldersgruppe?

A

25-35 år

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15
Q

Mixed connective tissue disease (MCTD)

hvor mange udvikler sig til storesøstersygdommene SLE og systemisk sklerodermi?

A

1/3

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16
Q

Mixed connective tissue disease (MCTD)

behandling?

A

Oftest symptomatisk, men ellers immunhæmmende (Methotrexat,azathioprin mm.)

17
Q

Sjøgrens syndrom

definition?

A

•Autoimmunttørhedssyndrom involverer eksokrine

kirtler.Evt sekundært til anden autoimmunsygdom typisk RA eller SLE

  • Træthed
  • Ledsmerter
18
Q

Sjøgrens syndrom

sjældne komplikationer?

A
  • Maligntlymfom i spytkirtel(risikox40) (også på halsen)
  • Interstitiel lungesygdom
  • Myositis (muskelbetændelse)
19
Q

Sjøgrens syndrom

prævalens?

A
  1. ud af 1000
20
Q

Sjøgrens syndrom

kønsfordeling?

A

90% kvinder

21
Q

Sjøgrens syndrom

aldersgruppe?

A

50-60 år

22
Q

Sjøgrens syndrom

behandling?

A

Behandlingafhængigafmanifestationer

  • Erstattetåreog spyt
  • Hydroksykloroquin
23
Q

Dermato-Polymyositis

nævn primære symptomer

A
24
Q

Dermato-Polymyositis

nævn “andre” symptomer

A
  • Almensymptomer – CANCER20%med Dermatomyositis
  • Lungeinvolvering– interstitiel lungesygdom
  • Hjerteinvolvering – ledningsforstyrrelser
  • Ledinvolvering
25
Q

Dermato-Polymyositis

prævalens?

A
  1. pr. million
26
Q

Dermato-Polymyositis

incidens?

A

5-10 pr. million

27
Q

Dermato-Polymyositis

kønsfordeling?

A

2/3 er kvinder

28
Q

Dermato-Polymyositis

hvilke undersøgelser udfører man?

A
  • ENG+ Muskelbiopsi
  • PET-CT
  • Autoantistoffer:ANA, ”myositisspecifikke”
29
Q

Dermato-Polymyositis

behandling?

A
30
Q

Sarcoidose

definition?

A

Definition:granulomatøssygdom,multiorganofte

inklusivelunger

31
Q

Sarcoidose

incidens?

A

100 pr. million

32
Q

Sarcoidose

kønsfordeling?

A

1:2 mænd vs. kvinder

33
Q

Sarcoidose

prognose?

A

God prognose. Sygdommen er ofte selvlimiterende med fuld remission indenfor 3 år for 66%

K2 - Bevægeapparatet og bloddannende organer (16 decks)

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