basic principles of antimicrobials Flashcards
1
Q
Spontaneous mutation v conjugation
A
spontaneous: random –> resistance to 1 drug
conjugation: 2 mocrobes switch DNA segments –> multi drug resistance
2
Q
what types of antibiotics are most likely to cause resistance
A
broad spectrum
3
Q
Superinfection
A
new infection that appears over the course of treatment for a primary infection
4
Q
immediate, accelerated, delayed reactions to drug
A
w/ hour
1-72 hrs
multiple days later
5
Q
Empiric therapy
A
broad spectrum antibiotic therapy used before causative organism is identified –> should be short term
6
Q
When are prophylactic meds appropriate
A
surgery (staph from skin)
bacterial endocarditis (before dental procedures)
neutropenia and transplant
7
Q
Monitoring antimicrobial therapy
A
if getting worse on antibiotics, its probably the wrong drug
