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pharm > Alzheimers > Flashcards

Alzheimers Flashcards

1
Q

what is it?

A

degeneration of neurons
reduced ACh

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2
Q

known risk factors

A

old age
fam history

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3
Q

2 types of drug therapy

A

Neuronal Receptor blocker: Memantine

Cholinesterase inhibitors: Donepzil, Galantamine, Rivastigmine

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4
Q

drug interactions

A

don’t take drugs that can block cholinergic receptors:
-1st gen antihistamines
-tricyclinc antidepressants
-conventional antipsychotics

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5
Q

adverse effects of cholinesterase inhibitprs

A

cholinergic side effects
GI issues
dizziness
headache
bronchoconstricion

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6
Q

Donepezil

A

mild to severe AD
watch out for falls and BRADYCARDIA

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7
Q

Rivastigmine

A

irreversible cholinesterase inhibition
WEIGHT LOSS
bad for ppl with basically any other health conditions

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8
Q

memantine

A

moderate to severe AD
better tolerated than cholinesterase inhibitors

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9
Q

Risperidone and Olanzapine

A

increase mortality from cardiovascular events and infection

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