Antifungals

Question 1

what kind of patient gets systemic fungal infections

Answer 1

super sick ones –> usually immunosuppressed

Question 2

4 classes of antifungals

Answer 2

polyene antibiotics
azoles
echinocandins
pyrimidine analogs

Question 3

Amphotericin B

Answer 3

drug of choice for most fungal infections
super toxic (kidneys, low potassium, bone marrow)

Question 4

Amphotericin B administration

Answer 4

Only IV, but tends to cause phlebitis, so picc or central line best
give with crystalloid to prevent renal issues
avoid other nephrotoxic drugs

Question 5

azoles

Answer 5

broad spectrum alternatives to Amphotericin B
less toxic and can be given PO, but reacts with a bunch of dif meds

Question 6

Fluconazole

Answer 6

fungistatic
good for yeast infections –> just one dose

Question 7

Voriconazole

Answer 7

candidemia
invasive aspergillosis
esophageal candidiasis

Question 8

Echinocandins

Answer 8

newest class of antifungals
disrupt fungal cell wall
Micafungin is main one
IV only

Question 9

Superficial mycoses

Answer 9

caused by candida and ringworm infections
treated with candidiasis
Nystatin is topical